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Blastic Plasmacytoid Dendritic Cell Neoplasm, a Very Rare Hematological Malignancy With Initial Cutaneous Involvement: A Case Report.
Acta Dermatovenerol Croat
November 2024
Prof. Miloš Nikolić, MD, PhD, University of Belgrade, School of Medicine,, Belgrade, Serbia;
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare and aggressive hematologic malignancy, arising from plasmacytoid dendritic cells (pDCs). BPDCN frequently has, at least initially, exclusively cutaneous presentation. We present a 45-year-old woman with a 3-month history of rapidly evolving violaceous patches, infiltrated plaques, and bruise-like tumefactions, disseminated on her face and upper trunk.
View Article and Find Full Text PDFIgE and cardiac disease.
Acta Physiol (Oxf)
February 2025
Department of Physiology, Pharmacology and Toxicology, West Virginia University, Morgantown, West Virginia, USA.
IgE acts primarily via the high affinity IgE receptor (FcεRI) and is central to immediate hypersensitivity reactions (anaphylaxis). However, IgE is also important in the development of chronic hypersensitivity reactions (allergy). In the cardiovascular system, numerous clinical studies have investigated serum IgE levels, mainly in the context of myocardial infarction, and have established a clear association between IgE and ischemic cardiac events.
View Article and Find Full Text PDFThe Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics.
J Am Soc Mass Spectrom
January 2025
MS Proteomics Research Group, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.
In recent years, alternative enzymes with varied specificities have gained importance in MS-based bottom-up proteomics, offering orthogonal information about biological samples and advantages in certain applications. However, most mass spectrometric workflows are optimized for tryptic digests. This raises the questions of whether enzyme specificity impacts mass spectrometry and if current methods for nontryptic digests are suboptimal.
View Article and Find Full Text PDFinfection in captive non-human primates in zoological gardens in Spain.
J Helminthol
January 2025
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain.
Currently, there is limited available information on the epidemiology of parasitic infections in captive non-human primates (NHPs) and their zoonotic potential. However, numerous cases of helminth infections in NHPs have been documented in several zoos around the world, with one of the most prevalent being those of the genus The main objective of this study is to investigate the occurrence of infection by spp. in primates from zoological gardens in Spain and to ascertain, at the species level, the specific species harbored by these hosts by using mitochondrial and ribosomal markers.
View Article and Find Full Text PDFEvaluating genomic selection and speed breeding for Fusarium head blight resistance in wheat using stochastic simulations.
Mol Breed
January 2025
Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, 1432 Ås, Norway.
Unlabelled: Genomic selection-based breeding programs offer significant advantages over conventional phenotypic selection, particularly in accelerating genetic gains in plant breeding, as demonstrated by simulations focused on combating Fusarium head blight (FHB) in wheat. FHB resistance, a crucial trait, is challenging to breed for due to its quantitative inheritance and environmental influence, leading to slow progress using conventional breeding methods. Stochastic simulations in our study compared various breeding schemes, incorporating genomic selection (GS) and combining it with speed breeding, against conventional phenotypic selection.
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