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Clearance of Protein-Bound Uremic Toxins Using Anion Nanotraps with Record High Uptake.
ACS Appl Mater Interfaces
December 2024
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
Article Synopsis
- Traditional hemodialysis is often ineffective at removing protein-bound uremic toxins (PBUTs) like -cresyl sulfate and indoxyl sulfate due to their strong attachment to serum albumin, which can lead to cardiovascular issues.
- A new class of cationic polymeric networks, CPN-X6-CPN-X9, shows exceptional capabilities in removing these toxins, with CPN-X7 and CPN-X6 achieving maximum sorption capacities that surpass any previously known materials.
- CPN-X9, which is hydrophobic, displays impressive selectivity in experiments and is able to recycle effectively over five cycles while maintaining good compatibility with blood.
The Inhibitory Effects of a Factor B-Binding DNA Aptamer Family Supersede the Gain of Function of Factor B Variants Associated with Atypical Hemolytic Uremic Syndrome.
J Immunol
December 2024
Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS.
Aptamers are short, single-stranded oligonucleotides that selectively bind to target biomolecules. Although they generally exhibit good binding specificity, their affinities are often limited because of the relative lack of hydrophobic groups in nucleic acids. Chemically modified nucleotides incorporating hydrophobic structures into uracil have been synthesized to address this obstacle.
View Article and Find Full Text PDFRandomized investigation of increased dialyzer membrane hydrophilicity on hemocompatibility and performance.
BMC Nephrol
July 2024
Fresenius Medical Care Deutschland GmbH, Global Biomedical Evidence Generation, Global Medical Office, 61352, Bad Homburg, Germany.
Background: Hemodialyzers should efficiently eliminate small and middle molecular uremic toxins and possess exceptional hemocompatibility to improve well-being of patients with end-stage kidney disease. However, performance and hemocompatibility get compromised during treatment due to adsorption of plasma proteins to the dialyzer membrane. Increased membrane hydrophilicity reduces protein adsorption to the membrane and was implemented in the novel FX CorAL dialyzer.
View Article and Find Full Text PDFApplication of Nanoparticles as Novel Adsorbents in Blood Purification Strategies.
Blood Purif
September 2024
Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Article Synopsis
- Blood purification therapies, like hemodialysis, can be improved through the integration of specially designed nanoparticles, making treatments more efficient for patients with metabolic toxin overload.
- Customized liposomes and nanoparticles have shown promising results in removing toxins from the blood, with studies indicating they are safe and effective in both preclinical and clinical settings.
- These innovations in nanomaterials could revolutionize dialysis and enhance support for patients with renal or hepatic failure, potentially leading to next-generation treatment options.
A novel hydrophilic polymer-coated magnetic nanomaterial based on the HILIC strategy for fast separation of glycopeptides and glycosylated exosomes.
Anal Bioanal Chem
September 2023
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.
Novel hydrophilic poly(N, N-methylenebisacrylamide/1,2-epoxy-5-hexene) coated magnetic nanospheres functionalized with 2-aminopurine (denoted as FeO@poly(MBA/EH)@2AP) for enriching glycopeptides and glycosylated exosomes were successfully obtained using a simple and green method on the basis of the HILIC (hydrophilic interaction liquid chromatography) enrichment strategy. The high density of polar groups endows the material with amazing hydrophilicity, enabling the nanomaterial to successfully capture glycopeptides and glycosylated exosomes within 1 min. Meanwhile, the materials demonstrated great sensitivity (0.
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