Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis rat model.

Objective: This research work aimed to assess the histopathological features and degree of gastritis severity in a rat model, induced by infection after administering omeprazole, amoxicillin, and clarithromycin as the standard first-line eradication regimen.

Material And Methods: Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control. Group 2 and Group 3 were treated as -inoculated groups. Group 2 was set as a positive control. Group 3 was administered omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen. Gastric histopathological examination was conducted. The difference in the severity of gastritis among the groups was examined using the one-way analysis of variance test. The significance was determined to be < 0.05.

Results: Gastritis was found in all inoculated groups. The severity of gastritis was highest in Group 2 ( < 0.05). We could see a refinement in gastritis severity after administering omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen (Group 3 Group 2; <0.05).

Conclusion: Gastritis, induced by the rat model, was found in all inoculated groups. There was a refinement in the degree of gastritis severity after the administration of omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen.