AI Article Synopsis
- Neem (A. Juss) is a tropical plant in Indonesia studied for its medicinal properties, particularly its effect on liver and kidney function in male rats.
- The study involved 24 male Wistar rats divided into four groups, with treatment groups receiving different doses of neem leaf ethanol extract over 48 days.
- Results indicated that while the extract did not significantly impact AST, ALT, and creatinine levels, it did reduce urea concentration, and no adverse effects were found in liver and kidney histology, suggesting the need for further safety evaluations of neem extracts in herbal medicine.
Article Abstract
Neem ( A. Juss) is one of the tropical plants found in Indonesia that has been used to prevent and treat various diseases. This study aimed to investigate the effect of the ethanol extract of neem leaves on the concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in male rats. Twenty-four male Wistar rats were randomly divided into four groups (T0, T1, T2, and T3) with 6 rats in each group. T0 is the control group, and T1, T2, and T3 are the treatment groups that were administered 100, 200, and 300 mg/kg body weight of neem leaf ethanolic extracts for 48 days, respectively. On day 49, blood samples were collected to measure the concentration of AST, ALT, creatinine, and urea followed by an evaluation of liver and kidney histology. The results showed that the ethanolic extract of neem leaves did not affect the concentration of AST, ALT, and creatinine, The ethanol leaves reduced extract on the urea concentration, no abnormal changes were observed in the liver and kidney organs. In the future, it is required to carry out a comprehensive safety evaluation of the neem leaf ethanol extract for herbal medicines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026305 | PMC |
| http://dx.doi.org/10.1155/2021/7970424 | DOI Listing |
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