AI Article Synopsis
- The tumor microenvironment (TME) is complex, featuring various cells and gradients of soluble molecules that influence cancer behavior.
- Current models for studying cancer cells often fall short in replicating this complexity, making it hard to analyze.
- A new 2D live-cell chamber mimics the TME, showing how breast cancer cells and macrophages create hypoxic and nutrient gradients that affect their organization and characteristics, providing deeper understanding of tumor development.
Article Abstract
The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that approximates the TME and demonstrate that breast cancer cells and macrophages generate hypoxic and nutrient gradients, self-organize, and have spatially varying phenotypes along the gradients, leading to new insights into tumorigenesis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050328 | PMC |
| http://dx.doi.org/10.1038/s42003-021-01954-0 | DOI Listing |
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