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Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.
Nat Med
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically validated for ultrasensitive ctDNA detection at 1-3 ppm of ctDNA with 99.
View Article and Find Full Text PDFPhylogenetics of Lepidonotopodini (Macellicephalinae, Polynoidae, Annelida) and Comparative Mitogenomics of Shallow-Water vs. Deep-Sea Scaleworms (Aphroditiformia).
Biology (Basel)
November 2024
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0202, USA.
Within Polynoidae, a diverse aphroditiform family, the subfamily Macellicephalinae comprises anchialine cave-dwelling and deep-sea scaleworms. In this study, Lepidonotopodinae is synonymized with Macellicephalinae, and the tribe Lepidonotopodini is applied to a well-supported clade inhabiting deep-sea chemosynthetic-based ecosystems. Newly sequenced "genome skimming" data for 30 deep-sea polynoids and the comparatively shallow living is used to bioinformatically assemble their mitogenomes.
View Article and Find Full Text PDFPredators in the Dark: Metabarcoding Reveals Arcellinida Communities Associated with Bat Guano, Endemic to Dinaric Karst in Croatia.
Microb Ecol
January 2025
Real Jardín Botánico (RJB-CSIC), C/ Moyano 1, 28014, Madrid, Spain.
Article Synopsis
- Karst caves are unique ecosystems with low organic matter and high endemic biodiversity, particularly in microbes like testate amoebae (Arcellinida).
- Recent research in Dinaric karstic caves, using metabarcoding techniques, reveals that bat guano significantly enhances the diversity and abundance of Arcellinida communities.
- Findings suggest that bat guano creates rich habitats for unique Arcellinida species, emphasizing the important ecological role of bats in these subterranean environments.
Successful osimertinib treatment for Meckel's cave metastasis: a case report.
Int Cancer Conf J
January 2025
Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa Japan.
Osimertinib has emerged as the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations, offering improved tolerability and demonstrating superior efficacy against brain metastases in comparison with other tyrosine kinase inhibitors. The Meckel's cave is a dural recess in the posteromedial part of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the anterior pontine cisterna and the cavernous sinus, and houses the Gasserian ganglion and proximal radicle of the trigeminal nerve. Trigeminal neuropathy, characterized by numbness and dysesthesia of the skin and mucous membranes of the face, poses diagnostic challenges and often requires differentiation from conditions, such as compression neuropathy, inflammation, and drug-induced reactions.
View Article and Find Full Text PDFA sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain.
Nat Commun
January 2025
Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Caves are primary sites for studying human and animal subsistence patterns and genetic ancestry throughout the Palaeolithic. Iberia served as a critical human and animal refugium in Europe during the Last Glacial Maximum (LGM), 26.5 to 19 thousand years before the present (cal kya).
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