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Location Has Prognostic Impact on the Outcome of Colorectal Mucinous Adenocarcinomas.
Cancers (Basel)
December 2023
Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Mucinous (colloid) adenocarcinomas (MAs) are a rare histological subtype of tumors defined by extracellular mucin comprising more than 50% of the tumor. These tumors are on a continuum of mucin-producing malignancies with signet ring cell adenocarcinomas (SRCCs), which instead produce intracellular mucin. Mucin-containing cancers occur primarily in the stomach and colon, where for SRCCs, outcomes are relatively worse in the proximal stomach and the rectum.
View Article and Find Full Text PDFMucin-Containing Rectal Cancer: A Review of Unique Imaging, Pathology, and Therapeutic Response Features.
Semin Roentgenol
April 2021
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC.
Mucin-Containing Rectal Carcinomas: Overview of Unique Clinical and Imaging Features.
AJR Am J Roentgenol
July 2019
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
The purpose of this study is to review the unique clinical and imaging features of mucin-containing rectal carcinomas. Mucinous rectal carcinoma is an uncommon tumor subtype with a worse prognosis. At MRI, it is marked by T2-hyperintense extracellular mucin.
View Article and Find Full Text PDFClinicopathologic features and prognostic analysis of MSI-high colon cancer.
Int J Colorectal Dis
March 2012
Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 11217, Taipei, Taiwan, Republic of China.
Purpose: The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated.
Methods: Microsatellite status was identified by genotyping.
Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats.
Dig Dis Sci
April 1997
Department of Surgery, Sahlgren Hospital, Sweden.
A rat model of colitis [dextran sulfate (DSS)] was used to study the permeation of Evans blue (EB) from the lumen into the wall of proximal and distal colonic loops after exposure to the dye for 2 hr. Topical application of drugs used in human ulcerative colitis (lidocaine, mesalazine, prednisolone, or sucralfate) was given daily during induction of colitis to protect the mucosa. The mucosal changes were evaluated with special regard to peptidergic innervation [substance P (SP) and neuropeptide Y (NPY)], invasion of antigen-presenting polydendritic cells, and mucin-containing goblet cells.
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