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http://dx.doi.org/10.1164/rccm.202103-0612ED | DOI Listing |
Int J Environ Res Public Health
January 2022
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
The origins of theories specifying dietary restraint as a cause of eating disorders can be traced to the 1970s. This paper will present an overview of the origins of dietary restraint theories and a brief historical review of evidence will be summarized. Recent research will be presented, including the results from the CALERIE Phase 1 study, as well as CALERIE Phase 2, which were NIH-sponsored randomized controlled trials.
View Article and Find Full Text PDFJAMA Oncol
October 2021
Department of Internal Medicine, UC Davis Comprehensive Cancer Center, Sacramento, California.
Importance: Preclinical studies suggest that inhibition of single-stranded DNA repair by ataxia telangiectasia and Rad3 (ATR) may enhance the cytotoxicity of cisplatin, gemcitabine, and other chemotherapeutic agents. Cisplatin with gemcitabine remains the standard up-front therapy for treatment in patients with metastatic urothelial cancer.
Objective: To determine whether the use of the selective ATR inhibitor, berzosertib, could augment the activity of cisplatin with gemcitabine.
Am J Respir Crit Care Med
July 2021
Department of Medicine University of Alberta Edmonton, Alberta, Canada.
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