AI Article Synopsis
- A meta-analysis was conducted to evaluate the safety and effectiveness of deep brain stimulation (DBS) under general anesthesia for dystonia patients, as evidence for its efficacy was previously lacking.
- The study analyzed data from 34 sources involving 341 patients, measuring improvements using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) after a mean follow-up of 22.4 months.
- Results showed significant improvement in dystonia symptoms post-surgery, with findings indicating that shorter disease duration correlates with better outcomes, while the procedure was generally safe with acceptable adverse events.
Article Abstract
Objective: The efficacy and safety of deep brain stimulation (DBS) under general anesthesia for the treatment of dystonia have not yet been confirmed with high level of evidence. This meta-analysis with pooled individual patient data aims to assess the clinical outcomes and identify the potential prognostic factors of dystonia patients who underwent general anesthesia DBS.
Methods: We searched PubMed, Web of Science, and Embase for articles describing patients with dystonia who underwent asleep DBS and had individual Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) scores. The relative improvement in BFMDRS scores was considered the primary outcome. Pearson correlation analyses and multivariate linear regression analysis were conducted to explore the prognostic factors.
Results: A total of 34 studies involving 341 patients were included. The mean postoperative improvement in BFMDRS-M (BFMDRS movement subscale) and BFMDRS-D (BFMDRS disability subscale) scores were 58.6±36.2% and 48.5±38.7% at the last follow-up visit, respectively, with a mean follow-up time of 22.4±27.6 months. Age at surgery and disease duration showed a negative correlation with the percent improvement of BFMDRS-M (%) at the last visit (r=-0.134, P=0.013; r=-0.165, P=0.006). In the stepwise multivariate regression, only disease duration remained a relevant factor. Additionally, the adverse events were acceptable.
Conclusion: General anesthesia DBS is a safe, effective, and feasible option for dystonia patients in the long term. Shorter disease duration predicts better clinical outcomes.
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| http://dx.doi.org/10.1007/s10072-021-05214-1 | DOI Listing |
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