5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan- induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
ynthesis anti-inflammatory
4
anti-inflammatory antioxidant
4
antioxidant activities
4
activities novel
4
novel 3h-thiazolo[45-b]pyridines
4
3h-thiazolo[45-b]pyridines 5-hydroxy-7-methyl-3h-thiazolo[45-b]pyridin-2-one
4
5-hydroxy-7-methyl-3h-thiazolo[45-b]pyridin-2-one reaction
4
reaction 4-iminothiazolidin-2-one
4
4-iminothiazolidin-2-one acetoacetic
4
acetoacetic ester
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!