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Cilostazol geno-protective effects mitigate carbamazepine-induced genotoxicity in human cultured blood lymphocytes.
Toxicol Rep
December 2024
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Background: Carbamazepine is one of the most widely used antiepileptic drugs. Carbamazepine has been shown to be toxic to cells. Cilostazol, an antiplatelet agent, has known antioxidant, antiproliferative, anti-inflammatory, and anti-tumor effects.
View Article and Find Full Text PDFImplementation of HLA-related genotype-guided prescribing in Singapore.
Am J Health Syst Pharm
October 2024
Department of Pharmacy, National University Hospital, Singapore, Singapore.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFEffects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity.
J Pharmacol Toxicol Methods
July 2024
Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Article Synopsis
- Standardization and validation of in vitro drug metabolism are crucial for drug development and toxicity testing, particularly in assays like the lymphocyte toxicity assay (LTA) and in vitro platelet toxicity assay (iPTA).
- The study focused on how the species of origin and different induction agents affect the metabolic capacities of isolated liver microsomes (MICs) when bioactivating carbamazepine (CBZ), with cytotoxicity as a key measure.
- Results showed that MICs from minipigs and rat MICs conditioned with 3-methylcholanthrene (3MC) produced the most cytotoxic metabolites, offering insights to improve in vitro toxicity assays and guiding pre-clinical drug investigations.
Economic Evaluation of HLA-B*15:02 Genotyping for Asian Australian Patients With Epilepsy.
JAMA Dermatol
June 2024
Faculty of Medicine and Health, University of New South Wales, Kensington, New South Wales, Australia.
Importance: The HLA-B*15:02 allele has been associated with an increased risk of carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in specific Asian populations (including Han Chinese, Malaysian, Thai, and Vietnamese individuals). While HLA-B*15:02 genotype testing in Asian populations is recommended by several international prescribing guidelines, it is not subsidized by the Medicare Benefits Schedule in Australia.
Objective: To evaluate the cost-effectiveness of HLA-B*15:02 genotyping in Asian Australian patients with epilepsy.
Carbamazepine-induced Stevens-Johnson syndrome progressing to toxic epidermal necrolysis: a rare clinical image.
Pan Afr Med J
April 2024
Department of Community Health Nursing, Smt. Radhikabai Meghe Memorial College of Nursing, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.
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