is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the discovery of nine unique iridoids and iridoid glycosides, including three new iridoids (-) and six previously unknown irioid glycosides (-), and one known compound (). Among them, compound was a deformed iridoid, while compounds , -, and formed a new ring in their skeletons which was uncommon in this genus. For compound , the new ring existed between C-3 and C-10, while a 1,3-dioxane appeared between C-7 and C-10 in compounds - and . Moreover, compound was a bis-iridoid glycoside, which was the first reported in . . And the sugar of irioid glycosides (-) was glucose at C-11, except in which had a 5-deoxyglucose moiety. All their structures were confirmed based on the extensive spectroscopic analysis, including IR, UV, HR-ESI-MS, ECD, and 1D- and 2D-NMR experiments. Their cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, SW480 were also tested.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039314 | PMC |
| http://dx.doi.org/10.3389/fchem.2021.657028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bis-Iridoid Glycosides and Triterpenoids from and Their Potential as Inhibitors of ACC1 and ACL.
Molecules
December 2024
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Pharmaceutical Sciences, Taizhou University, Taizhou 318000, China.
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of , a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (- and -), 20 triterpenoids (, , and -), and 8 phenylpropanoids (-). Among these, amabiliosides A () and B () represent previously undescribed bis-iridoid glycosides, while amabiliosides C () and D () feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro--carboline-5-carboxylic acid moiety.
View Article and Find Full Text PDFA Comprehensive Quality Evaluation for Gentiana Rigescens Franch. by Fingerprinting Combined with Chemometrics and Network Pharmacology.
Chem Biodivers
October 2024
College of Traditional Chinese Medicine & Yunnan Key Laboratory of Southern Medicinal Resources, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Gentiana rigescens Franch. (G. rigescens) is a unique traditional medicinal herb from southwestern China, and its clinical mechanism for the treatment of hepatitis and the quality differences between different origins are not clear.
View Article and Find Full Text PDFInvestigating the Therapeutic Property of Galium verum L. (GV) for MSG induced Audiogenic Epilepsy (AEs) and Neuroprotection through In-Silico and In-Vitro Analysis.
Cent Nerv Syst Agents Med Chem
August 2024
Institute of Pharmaceutical Research, GLA University Mathura, Uttar Pradesh-281406, India.
Background: Audiogenic Epilepsy (AEs) is a subtype of epileptic seizure that is generally caused by high-intensity sounds. A large number of traditional medicines has been explored in this lieu where our study chased Galium verum L. (Rubiaceae), an herbal plant which is commonly known as Lady's Bedstraw, that contains a highly rich chemical composition including flavonoids (Hispidulin, Quercetin, and Kaempferol), and phenolic acids (chlorogenic acid, caftaric acid, and gallic acid).
View Article and Find Full Text PDFCharacterization of a vacuolar importer of secologanin in Catharanthus roseus.
Commun Biol
August 2024
Plant Science, McGill University, Sainte-Anne-de-Bellevue, QC, H9X 3V9, Canada.
Article Synopsis
- The biosynthesis of monoterpenoid indole alkaloids (MIAs) in the plant Catharanthus roseus showcases complex metabolic processes occurring in various tissues and cell types, emphasizing the need for inter-cellular and organellar transport.
- Researchers identified a specific transporter, CrMATE1, that imports secologanin into vacuoles and found that altering its function changes the plant's alkaloid profiles.
- CrMATE1 has a high specificity for secologanin and efficiently transports it, illustrating its crucial role in regulating metabolic pathways related to plant defense and balance.
Research Progress of and Predictive Analysis of Quality Markers Based on Network Pharmacology.
Curr Pharm Biotechnol
June 2024
School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China.
Du Zhong is a valuable Chinese medicinal herb unique to China. It is a national second- class precious protected tree, known as "plant gold", which has been used to treat various diseases since ancient times. The main active ingredients are lignans, phenylprophetons, flavonoids, iridoids and steroids and terpenoids, which have pharmacological effects such as lowering blood pressure, enhancing immunity, regulating bone metabolism, protecting nerve cells, protecting liver and gallbladder and regulating blood lipids.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!