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| http://dx.doi.org/10.1016/j.jds.2020.08.011 | DOI Listing |
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Metoprolol adverse events and literature analyses: case/non-case analyses using the FDA Adverse Event Reporting System (FAERS).
Expert Opin Drug Saf
December 2024
Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.
Background: In recent years, β-blockers such as metoprolol have been upgraded to first-line antihypertensive drugs. However, metoprolol demonstrates poor prognosis effects on diseases such as stroke. Further clinical application may expand the possibility of its related adverse reactions.
View Article and Find Full Text PDFSuspected trigeminocardiac reflex following maxillary nerve block in a brachycephalic dog.
Vet Anaesth Analg
October 2024
Davies Veterinary Specialists, part of Linnaeus Veterinary Limited, Hitchin, UK.
Comparison of Remimazolam and Propofol for Intravenous Anesthesia on Trigeminocardiac Reflex in Percutaneous Balloon Compression for Trigeminal Neuralgia: A Randomized Controlled Trial.
Drug Des Devel Ther
November 2024
Department of Anesthesiology and Pain Management, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Article Synopsis
- Trigeminal neuralgia causes severe facial pain, and percutaneous balloon compression (PBC) is a common treatment, though it can provoke trigeminocardiac reflex (TCR), resulting in heart complications.
- This study compares the effects of remimazolam and propofol anesthesia on the occurrence of TCR during PBC in patients with trigeminal neuralgia.
- Results showed that remimazolam significantly reduced the incidence of TCR and severe TCR compared to propofol, while also maintaining a higher heart rate, with no increase in adverse events.
Dexmedetomidine: a real-world safety analysis based on FDA adverse event reporting system database.
Front Pharmacol
August 2024
Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Objective: Using the FDA adverse event reporting system (FAERS) database to analyze the safety profile of Dexmedetomidine and provide guidance for clinical application.
Methods: Data from the FAERS database from the first quarter of 2004 to the third quarter of 2023 were collected. Reporting odds ratio (ROR), the proportional reporting ratio (PRR), and the Bayesian confidence propagation neural network (BCPNN) were employed to detect and assess adverse events associated with Dexmedetomidine.
Intra-operative hypertension as a predictor of surgical outcomes in microvascular decompression surgery for trigeminal neuralgia.
Acta Neurochir (Wien)
July 2024
Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, FL, USA.
Purpose: The trigeminocardiac reflex (TCR) has traditionally been characterized by a sudden decrease in heart rate, asystole, or hypotension during the manipulation of the trigeminal nerve (MTN) or its branches. While this classical TCR is well-documented, there is limited literature on alternative forms of TCR, such as the development of intraoperative hypertension (HTN) or tachycardia, and the underlying pathogenesis. Furthermore, a gap exists in understanding the correlation between intraoperative blood pressure readings and postoperative outcomes, particularly regarding pain relief in patients with trigeminal neuralgia (TN).
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