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Prognostic Nutritional Index identifies risk of early progression and survival outcomes in Advanced Non-small Cell Lung Cancer patients treated with PD-1 inhibitors. | LitMetric

AI Article Synopsis

  • The study explores the prognostic nutritional index (PNI) as a potential predictor for outcomes in patients with advanced non-small cell lung cancer (NSCLC) undergoing treatment with PD-1 inhibitors.
  • Researchers analyzed data from 123 patients, finding that a low PNI is significantly associated with early progression of the disease and worse survival rates.
  • A nomogram was developed based on these results to help predict patient prognosis, with moderate accuracy in forecasting survival outcomes linked to PNI levels.

Article Abstract

The prognostic nutritional index (PNI) is related to the prognosis of multiple malignancies. This study investigated whether the PNI has prognostic value in advanced non-small cell lung cancer (NSCLC) patients treated with programmed death 1 (PD-1) inhibitors. We retrospectively analyzed advanced NSCLC patients treated with PD-1 inhibitors from July 2018 to December 2019. Pretreatment PNI was calculated by peripheral lymphocyte count and serum albumin level, and the cut-off value was determined. Subsequently, we investigated the relationship between PNI and early progression, and evaluated its prognostic role on survival outcomes. Ultimately, based on the results of survival analysis, a nomogram was established. A total of 123 patients were included. Of these, 24 (19.5%) patients had experienced early progression. Multivariate logistic analysis indicated that low PNI (odds ratio, 3.709, 95% confidence interval [CI], 1.354-10.161; = 0.011) was closely correlated with early progression. Moreover, multivariate Cox regression analysis confirmed that low PNI was an independent risk factor for progression-free survival (hazard ratio [HR], 2.698, 95% CI, 1.752-4.153; < 0.001) and overall survival (HR, 7.222, 95% CI, 4.081-12.781; < 0.001), respectively. The prediction accuracy of nomogram based on PNI is moderate. PNI was an independent predictor of early progression and survival outcomes in advanced NSCLC patients treated with PD-1 inhibitors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040881PMC
http://dx.doi.org/10.7150/jca.55936DOI Listing

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