AI Article Synopsis
- A 57-year-old patient underwent an ABO-incompatible living kidney transplant and developed signs of de novo Thrombotic Microangiopathy (TMA) three days post-op.
- Laboratory tests confirmed TMA and the patient’s kidney function showed stagnation despite initial treatment efforts.
- Administering eculizumab on days 3 and 10 post-surgery successfully managed the TMA, prompting a discussion about its early use to potentially prevent graft dysfunction and improve outcomes for transplant patients.
Article Abstract
History: We report a 57-year-old patient admitted to our hospital for planned AB0-incompatible living kidney transplantation.
Findings And Diagnosis: On day 3 post operationem, clear laboratory evidence of de novo TMA developed. Renal detoxification stagnated with initial regular course.
Therapy And Course: By using eculizumab 900 mg on d3 and d10 post operationem, we were able to suppress TMA with a sustained success.
Conclusion: It has to be discussed whether an early use of eculizumab in cases of suspected de novo TMA is a safe way to prevent graft dysfunction and thus to improve the poor prognosis for graft and recipient described in the literature.
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- A 57-year-old patient underwent an ABO-incompatible living kidney transplant and developed signs of de novo Thrombotic Microangiopathy (TMA) three days post-op.
- Laboratory tests confirmed TMA and the patient’s kidney function showed stagnation despite initial treatment efforts.
- Administering eculizumab on days 3 and 10 post-surgery successfully managed the TMA, prompting a discussion about its early use to potentially prevent graft dysfunction and improve outcomes for transplant patients.
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