AI Article Synopsis
- Genetic and epigenetic factors together influence the progression of complex diseases, particularly in multiple sclerosis (MS).
- Research was conducted comparing global DNA methylation in lymphocytes and monocytes of MS patients to that of healthy controls, involving 33 patients with relapsing-remitting MS (RRMS) and 5 healthy subjects.
- The study found distinct DNA methylation patterns based on cell type, noting that monocyte methylation levels were significantly altered after treatment with IFNβ.
Article Abstract
The combination of genetic and epigenetic influences alters the development of complex diseases. Aberrant patterns of DNA methylation are associated with inflammation and clinical activity in MS. We evaluated the differences between global DNA methylation in lymphocytes and monocytes of patients with MS compared to healthy controls. Thirty-three patients with RRMS (PwRMS) and five healthy individuals were included. DNA was isolated from PBMCs by a phenol-chloroform method, and global methylation was analyzed by Imprint® Methylated DNA Quantification Kit. We observed a cell-type-specific DNA methylation pattern and showed that monocyte global DNA methylation was significantly affected by IFNβ treatment.
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| http://dx.doi.org/10.1016/j.jneuroim.2021.577563 | DOI Listing |
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