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Dapagliflozin treatment and cardiovascular outcome in RBP4/TTR (transthyretin cardiac amyloidosis) mice.
ESC Heart Fail
February 2024
Department of Endocrinology and Metabolism, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Aims: Whether sodium-glucose co-transporter 2 inhibitors are effective for heart failure caused by ATTR-CA (transthyretin cardiac amyloidosis) remains uncertain. The aim of this study is to investigate the cardiovascular prognosis in ATTR-CA mice model with dapagliflozin treatment.
Methods And Results: Humanized RBP4/TTR and RBP4/TTR mice models were constructed with clustered regularly interspaced short palindromic repeats and associated Cas9 endonuclease (CRISPR-Cas9) techniques and multiple generations breeding.
Emerging Role of Scintigraphy Using Bone-Seeking Tracers for Diagnosis of Cardiac Amyloidosis: Expert Panel Narrative Review.
AJR Am J Roentgenol
January 2024
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Article Synopsis
- Amyloidoses are diseases caused by the misfolding and accumulation of proteins, leading to problems in organs, with transthyretin amyloidosis (ATTR) and light-chain amyloidosis (AL) being the most common types affecting the heart.
- Diagnosing ATTR cardiomyopathy (ATTR-CM) is difficult due to its similarities with other heart diseases and past reliance on invasive endomyocardial biopsy; however, noninvasive myocardial scintigraphy using bone-seeking tracers is now a highly accurate diagnostic method and has changed how the condition is diagnosed.
- The review details the use of scintigraphy, including the available tracers, techniques for acquiring images, how to interpret results, common mistakes, and necessary
Ocular Involvement in Hereditary Amyloidosis.
Genes (Basel)
June 2021
Amyloidosis Research and Treatment Centre, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy.
The term amyloidosis describes a group of rare diseases caused by protein conformation abnormalities resulting in extracellular deposition and accumulation of insoluble fibrillar aggregates. So far, 36 amyloid precursor proteins have been identified, and each one is responsible for a specific disease entity. Transthyretin amyloidosis (ATTRv) is one of the most common forms of systemic and ocular amyloidosis, due to the deposition of transthyretin (TTR), which is a transport protein mainly synthesized in the liver but also in the retinal pigment epithelial cells.
View Article and Find Full Text PDFTransforming ATTR cardiac amyloidosis into a chronic disease: The enormous potential of quantitative SPECT to improve diagnosis, prognosis, and monitoring of disease progression.
J Nucl Cardiol
October 2021
Division of Cardiovascular Medicine and the Cardiac Imaging Center, University of Virginia Health System, Charlottesville, VA, USA.
Myocardial Amyloidosis: The Exemplar Interstitial Disease.
JACC Cardiovasc Imaging
November 2019
Institute of Cardiovascular Sciences, University College London, London, United Kingdom; Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom.
Cardiac involvement drives prognosis and treatment choices in cardiac amyloidosis. Echocardiography is the first-line examination for patients presenting with heart failure, and it is the imaging modality that most often raises the suspicion of cardiac amyloidosis. Echocardiography can provide an assessment of the likelihood of cardiac amyloid infiltration versus other hypertrophic phenocopies and can assess the severity of cardiac involvement.
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