-Derived Extract β-Aescin and Antibacterial Activity.

Objectives: The objective of this study was to investigate the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria.

Materials And Methods: Agar well diffusion assay was used to determine the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria including and . Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of β-aescin were evaluated by serial dilution method.

Results: β-aescin led to significant antibacterial effects on the tested Gram-negative and Gram-positive bacteria compared to the negative control, < 0.05 for and and < 0.01 for and . On the other hand, β-aescin produced a comparable less antibacterial effect on and compared to the positive control, < 0.01, whereas β-aescin illustrated a comparable effect with that of the positive control on Gram-positive = 0.05. Furthermore, β-aescin illustrated a concentration-dependent antibacterial effect against Gram-positive and compared to the different concentrations, < 0.01. MIC and MBC of β-aescin were high for Gram-negative bacteria and low for Gram-positive bacteria compared to MIC of the positive control.

Conclusions: β-aescin is an effective antibacterial herb mainly against Gram-positive and in a concentration-dependent manner.