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Introduction: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear.
Methods: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure.
Results: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels.
Conclusion: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.
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http://dx.doi.org/10.32598/bcn.11.6.1100.1 | DOI Listing |
Water Res
December 2024
State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, PR China; State Key Laboratory of Urban Water Resource and Environment, School of Civil and Environmental Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, 518055, PR China. Electronic address:
Organohalide-respiring bacteria (OHRB) play a key role in facilitating the detoxification of halogenated organics, but their slow growth and harsh growth conditions often limit their application in field remediation. In this study, we investigated the metabolic performance and organohalide respiration process of a non-obligate OHRB, Pseudomonas sp. CP-1, demonstrating favorable anaerobic reductive dechlorination ability of 2,4,6-trichlorophenol to 4-chlorophenol with a removal rate constant (k) of 0.
View Article and Find Full Text PDFAntonie Van Leeuwenhoek
December 2024
Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
A Gram-stain-negative, aerobic, non-spore-forming, non-motile, coccus-shaped, and red-pigmented bacterial strain designated as CJ14 was isolated from lettuce cultivation soil in Yong-In, South Korea. Strain CJ14 grew optimally on Luria-Bertani agar at 37 ℃ and pH 7.0 in the absence of NaCl.
View Article and Find Full Text PDFHeliyon
October 2024
Department of Civil and Environmental Engineering, Nagaoka University of Technology, Niigata, 940-2188, Japan.
A novel, gelatinous, colony-forming, rod-shaped bacterial strain, designated IK01 was isolated from biofilms formed on the membrane surface of a sewage-treating membrane bioreactor (MBR). Strain IK01 produced gelatinous and almost transparent colonies at lower medium concentrations. Fourier transform infrared analysis of the gelatinous colony matrix showed that the matrix could be a biofilm substance.
View Article and Find Full Text PDFMicroPubl Biol
December 2024
School of Biological Sciences, University of Oklahoma, Norman, Oklahoma, United States.
The evolution of developmental rates may drive morphological change. develops nearly twice as slowly as . encodes a hydroxylase required for synthesizing ubiquinone, and mutant slow growth phenotypes can be rescued by supplying animals with a ubiquinone precursor analogue, 2,4-dihydroxybenzoate.
View Article and Find Full Text PDFEpilepsy Behav Rep
October 2024
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
This case series describes the clinical features, diagnostic challenges, treatment approaches, and outcomes of three adult patients with COQ8A-related CoQ10 deficiency presenting with focal status epilepticus, who were effectively treated at the Department of Neurology, Philipps University Marburg, Marburg, Germany. The patients, all from consanguineous families with the first two being siblings, presented with a late onset of the disease, characterized by progressive cerebellar ataxia and epilepsy, with clinical deterioration and focal status epilepticus occurring in adulthood. The first patient exhibited myoclonic status, while the second and third patients presented with bilateral tonic-clonic seizures followed by focal status epilepticus manifesting with cortical blindness.
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