AI Article Synopsis
- The study focused on creating mixed polymer-lipid nanoparticles (PLNs) specifically for ibuprofen delivery using a modified emulsification solvent evaporation technique.
- The resulting nanoparticles had sizes ranging from 193.3 to 795.8 nanometers, with a negative ζ potential indicating stability, and showed a high drug entrapment efficiency between 80.3% and 93.6%.
- Pharmacokinetic analysis revealed that the PLNs significantly enhanced the concentration and time profile of ibuprofen in comparison to traditional formulations, suggesting improved bioavailability of the drug.
Article Abstract
The aim of this study was to design and formulate mixed polymer-lipid nanoparticles (PLNs) for the delivery of ibuprofen. The mixed PLNs were prepared by a single modified emulsification solvent evaporation method. Core-shell-shaped mixed PLNs were successfully prepared, with sizes in the nano range (193.3 ± 0.70 to 795.8 ± 0.70 nm) and ζ potential (-26.8 ± 0.45 to -42.8 ± 0.30 mV). Entrapment efficiency ranged from 80.3 to 93.6%. Pharmacokinetic parameters showed great improvement in C and T of ibuprofen from the formulation PLNs8 compared with the respective Brufen and pure drugs, indicating improvement in bioavailability of the drug.
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| http://dx.doi.org/10.4155/tde-2020-0125 | DOI Listing |
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