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Electrochemical Study and Determination of Homovanillic Acid, the Final Metabolite of Dopamine, Using an Unmodified Disposable Electrode.
Molecules
January 2025
Department of Analytical Chemistry and Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Avenue 90-92, District 5, 050663 Bucharest, Romania.
This paper summarizes the main findings of a study which aimed to examine the electrochemical oxidation of homovanillic acid (HVA), the final metabolite of dopamine. A pencil graphite electrode (PGE) was used as working electrode and the measurements were performed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The type and the composition of the graphite leads used as PGE, the pH of the supporting electrolyte, as well as the scan rates were optimized by CV.
View Article and Find Full Text PDFCharacterising a New Sheep Model of Parkinson's Disease Using Unilateral Intracerebral Injection of 6-Hydroxydopamine Into the Substantia Nigra.
Eur J Neurosci
January 2025
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
New therapeutic agents developed for treating neurological disorders are often tested successfully on rodents. Testing in an appropriate large animal model where there is longer lifespan and comparable brain size to humans should improve translational success and is frequently expected by regulatory bodies. In this project, we aimed to establish a novel sheep model of Parkinson's disease as a large-brained experimental model for translational research.
View Article and Find Full Text PDFLeveraging supported liquid extraction and automated workflow for high efficiency and high quality clinical LC-MS/MS method for quantification of urinary 5-hydroxyindoleacetic acid (5-HIAA), vanillylmandelic acid (VMA) and homovanillic acid (HVA).
Clin Chim Acta
January 2025
Medical-Scientific Department, LifeLabs Medical Laboratory Services, Toronto, ON M9W 6J6, Canada. Electronic address:
Article Synopsis
- The study aimed to improve the efficiency of measuring neurotransmitter metabolites (5-HIAA, VMA, and HVA) in urine, which are crucial for diagnosing neuroendocrine tumors, through automation.
- The method involved using automated supported liquid extraction (SLE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) for accurate measurement and analysis of these metabolites.
- Results showed high recovery rates and successful validation across various performance criteria, with automation leading to significant time savings in the process.
Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA.
Physiol Res
November 2024
Laboratory of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Effort-based decision-making is particularly relevant to psychiatric conditions where motivation deficits are prominent features. Despite its clinical significance, the neurochemical mechanisms of this cognitive process remain unclarified. This study explores the impact of serotonin synthesis inhibition (PCPA) and modulation of serotonin release and 5-HT1A receptor agonism (8-OH-DPAT) on effort-based decision-making in rats.
View Article and Find Full Text PDFLethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood-brain barrier permeability in female CLP mice.
Intensive Care Med Exp
November 2024
Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstraße 13, 1200, Vienna, Austria.
Background: Septic encephalopathy is frequent but its pathophysiology is enigmatic. We studied expression of neurotransmitters, inflammation and integrity of the blood-brain barrier (BBB) in several brain regions during abdominal sepsis. We compared mice with either lethal or surviving phenotype in the first 4 sepsis days.
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