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Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management.
Hum Vaccin Immunother
December 2024
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Kounis syndrome is an acute coronary syndrome triggered by allergic mediators that induce coronary vasoconstriction and thrombosis, leading to further myocardial damage and anaphylactic shock. Kounis syndrome is also a rare but severe adverse reaction to the COVID-19 vaccine, a phenomenon that underscores the importance of collecting and analyzing similar cases to improve treatment and prognosis. Through comprehensive searches of the Web of Science, Embase, and PubMed databases, this study aimed to gather detailed patient data on patients who developed Kounis syndrome after receiving the COVID-19 vaccine and to further investigate the possible underlying mechanisms using currently available studies.
View Article and Find Full Text PDFSubacute Stent Thrombosis Related to Kounis Syndrome During Anaphylaxis Induced by Ultrasound Contrast Agent Infusion.
JACC Case Rep
November 2024
Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Article Synopsis
- A 44-year-old man experienced a severe allergic reaction after receiving SonoVue during a heart test, leading to chest pain and a heart attack caused by stent thrombosis and coronary vasospasm.
- Treatment involved mechanical thrombectomy, stent replacement, and careful management to avoid worsening the patient's condition, ultimately resulting in his recovery and discharge with normal heart function.
Drug-induced Kounis Syndrome: A Retrospective Pharmacovigilance Study from the FAERS and JADER Databases.
J Investig Allergol Clin Immunol
November 2024
Department of Cardiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
ATAK Complex Induced by Ranitidine: A Comprehensive Concept for Cardiac Involvement in Allergic Reactions.
J Investig Allergol Clin Immunol
November 2024
Department of Allergy, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Hospital Universitario de La Princesa, Madrid, Spain.
Kounis syndrome (KS) was first described in 1991 by Kounis and Zavras and is also known as allergic angina syndrome or allergy myocardial infarction. It is a rare, and frequently undiagnosed syndrome that is characterized by an anaphylactic reaction. Allergens cause massive degranulation of mast cells leading to coronary spasm, microvascular angina, and/or endothelial dysfunction with myocardial infarction.
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