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Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model.
PLoS One
December 2024
Fondazione Istituto di Ricerca Pediatrica Città della Speranza (IRP), Padova, Italy.
The zebrafish (Danio rerio) is a valuable model organism for studying human biology due to its easy genetic manipulation and small size. It is optically transparent and shares genetic similarities with humans, making it ideal for studying developmental processes, diseases, and drug screening via imaging-based approaches. Solid malignant tumors often contain hypoxic areas that stimulate the release of extracellular vesicles (EVs), lipid-bound structures released by cells into the extracellular space, that facilitate short- and long-range intercellular communication and metastatization.
View Article and Find Full Text PDFSimplified and reproducible laparoscopic complete mesocolic excision with D3 right hemicolectomy.
Colorectal Dis
January 2025
Department of Surgical Oncology, Prolife Cancer Centre and Research Institute, Pune, India.
Article Synopsis
- Laparoscopic complete mesocolic excision (CME) with D3 lymphadenectomy for right colon cancer is becoming more accepted, but it's not yet standardized like other surgical procedures; this study presents 10 straightforward, reproducible steps to improve the surgery's ergonomics and vascular anatomy identification.
- The procedure involves adopting the French position with specific port placements designed for optimal comfort and access, allowing surgeons to efficiently dissect alongside major vascular structures like the superior mesenteric artery (SMA).
- Identifying important anatomical landmarks, specifically the ligamentum teres and SMA/superior mesenteric vein (SMV) axis, is crucial for avoiding injury during dissection, making the surgical approach both effective and safer.
Dental Pulp Stem Cell Conditioned Medium Enhance Osteoblastic Differentiation and Bone Regeneration.
Stem Cell Rev Rep
November 2024
LBN, Univ. Montpellier, Montpellier, France.
Background: Cell-free approaches, utilizing mesenchymal stem cell secretome, have promising prospects in various fields of regenerative medicine. In this study, we examined in vitro and in vivo the potential of dental pulp stem cell-conditioned medium (DPSC-CM) for bone regeneration.
Methods: The secretome of undifferentiated stem cells from dental pulp were collected, and the effects of this DPSC-CM were assessed for osteodifferentiation of osteoblast-like cells (MG-63) and osteoblasts deriving from DPSC.
Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice.
J Vis Exp
October 2024
Department of Anesthesiology, University of Virginia;
Article Synopsis
- - Silicon multielectrode recordings help researchers study neuronal activity at high temporal resolution, but accessing deep brain structures like the brainstem poses challenges due to the risk of injuring major blood vessels.
- - To avoid these dangers, researchers developed an angled probe insertion technique that targets the brainstem while bypassing large veins, allowing for better access to various brain regions.
- - Using this method, scientists successfully recorded neuronal activity in the ventrolateral periaqueductal gray (vlPAG) related to REM sleep, enhancing the understanding of its connection to anesthesia in mice.
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