Aryne Multicomponent Reactions by Directed C-H Activation.

Chemistry

College of Pharmacy, Thomas Jefferson University, 1020 Locust street, Philadelphia, PA 19107, USA.

Published: June 2021

Arylation via ortho C-H activation by the aid of directing groups has been explored recently by many researchers. Herein, a palladium-catalyzed C-H arylation using 8-aminoquinoline as a bidentate directing group has been developed. The reaction furnishes only C-H arylation, unlike previous methods where cyclization to corresponding isoquinolones is observed. More interestingly, sequential C-H functionalization was observed when methylacrylate and acrylonitrile was added; this led to C-H olefination with the aryl group, which was installed from the aryne precursor.

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http://dx.doi.org/10.1002/chem.202100205DOI Listing

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