Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/lary.29567 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Near-Native Imaging of Metal Ion-Initiated Cell State Transition.
ACS Nano
January 2025
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, China.
Metal ions are indispensable to life, as they can serve as essential enzyme cofactors to drive fundamental biochemical reactions, yet paradoxically, excess is highly toxic. Higher-order cells have evolved functionally distinct organelles that separate and coordinate sophisticated biochemical processes to maintain cellular homeostasis upon metal ion stimuli. Here, we uncover the remodeling of subcellular architecture and organellar interactome in yeast initiated by several metal ion stimulations, relying on near-native three-dimensional imaging, cryo-soft X-ray tomography.
View Article and Find Full Text PDFThe dose-response relationship between noise-induced hearing loss and cumulative noise exposure adjusted by the effect of hearing protection devices among workers in Southern China.
J Occup Environ Hyg
January 2025
Institute of Physical Factors and Occupational Health, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong Province, China.
The noise exposure levels of workers wearing hearing protective devices (HPDs) depend on ambient noise and the protective effect of hearing protectors. This cross-sectional study aimed to adjust for cumulative noise exposure (CNE) based on the effective protection of hearing protection devices and explore the dose-response relationship between noise-induced hearing loss (NIHL) and adjusted cumulative noise exposure. A questionnaire was used to acquire the basic characteristics and occupational information of noise-exposed workers.
View Article and Find Full Text PDFEndothelial-specific knockout of the scramblase TMEM16F impairs in vivo clot formation.
Shock
January 2025
Pharmacology, University of Vermont, Burlington, VT.
Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott Syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not well understood. We sought to test the hypothesis that endothelial TMEM16F contributes to hemostasis by measuring bleeding time and venous clotting in endothelial-specific knockout (ECKO) mice.
View Article and Find Full Text PDFEfficacy and safety of dapsone in adult primary immune thrombocytopenia.
Blood Adv
January 2025
Hôpital Henri Mondor, Créteil, France.
To assess efficacy and safety of dapsone in adult immune thrombocytopenia (ITP), a multicenter randomized controlled trial (RCT) and a real-word study cohort were performed. Participants were adults with primary ITP, transient response to corticosteroids ± intravenous immunoglobulin, and a platelet count ≤ 30x109/L (or ≤ 50x109/L with bleeding). Patients in the RCT were randomized in arm A (prednisone x3weeks+dapsone for 12 months) or arm B (prednisone alone).
View Article and Find Full Text PDFThe biomechanical implications of lacunar and perilacunar microarchitecture on microdamage accumulation in cortical bone.
Acta Bioeng Biomech
June 2024
3School of Mechanical Engineering, Yanshan University, Hebei, China.
: This study aimed to explore how the microarchitectural features of lacunae and perilacunar zones impact the biomechanics of microdamage accumulation in cortical bone, crucial for understanding bone disorders' pathogenesis and developing preventive measures. : Utilizing the phase field finite element method, the study analyzed three bone unit models with varying microarchitecture: one without lacunae, one with lacunae and one including perilacunar zones, to assess their effects on cortical bone's biomechanical properties. : The presence of lacunae was found to increase microcrack initiation risk, acting as nucleation points and accelerating microcrack propagation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!