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| http://dx.doi.org/10.7554/eLife.69260 | DOI Listing |
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Surveillance of laboratory exposures to human pathogens and toxins, Canada, 2023.
Can Commun Dis Rep
January 2025
Regulatory, Operations and Emergency Management Branch, Public Health Agency of Canada, Ottawa, ON.
Background: The Public Health Agency of Canada oversees the and , and monitors human pathogen and toxin incidents in licensed facilities to minimize exposure impact at the individual and population level.
Objective: To provide an overview of confirmed laboratory exposure incidents in Canada in 2023.
Methods: Confirmed exposure incident reports in 2023 were analyzed using R 4.
Unveiling the molecular mechanisms of recurrent miscarriage through endoplasmic reticulum stress related gene expression.
Sci Rep
January 2025
Department of TCM, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Recurrent miscarriage (RM) is a reproductive disorder affecting couples worldwide. The underlying molecular mechanisms remain elusive, even though emerging evidence has implicated endoplasmic reticulum stress (ERS). We investigated RM- and ERS-related genes to develop a diagnostic model that can enhance predictive ability.
View Article and Find Full Text PDFGaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China.
Heart
January 2025
Heart Failure Center, Department of Cardiology, China-Japan Friendship Hospital, Beijing, China
Background: Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown.
Methods And Results: An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Are Exposure Recommendations for QT Evaluation Being Fulfilled?
J Clin Pharmacol
January 2025
Department of Clinical Medicine (Pharmaceutical Medicine), Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
Pharmaceutical companies have several options to evaluate drug-induced QT prolongation, often referred to as QT pathways, during clinical development. Current regulatory practices recommend achieving high clinical exposure (HCE) for conventional thorough QT (TQT) studies. An alternative to the TQT study, commonly known as the Q&A 5.
View Article and Find Full Text PDFNon-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi).
Arch Toxicol
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Translational Center Regenerative Therapies (TLC-RT), Fraunhofer Institute for Silicate Research (ISC), Röntgenring 12, 97070, Würzburg, Germany.
The potential risk of chemicals to the human eye is assessed by adopted test guidelines (TGs) for regulatory purposes to ensure consumer safety. Over the past decade, the Organization for Economic Co-operation and Development (OECD) has approved new approach methodologies (NAMs) to predict chemical eye damage. However, existing NAMs remain associated with limitations: First, no full replacement of the in vivo Draize eye test due to limited predictability of severe/mild damage was reached.
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