Dopamine Prevents Ultraviolet B-induced Development and Progression of Premalignant Cutaneous Lesions through its D Receptors.

Although the role of dopamine (DA) in malignant tumors has been reported, its function in premalignant lesions is unknown. Herein we report that the stimulation of DA D receptors in endothelial cells in ultraviolet B (UVB)-induced cutaneous lesions in mice significantly reduced the tumor number, tumor burden, and malignant squamous cell carcinoma in these animals. DA D receptor agonist inhibited VEGFA-dependent proangiogenic genes and . However, the mice pretreated with selective DA D receptor antagonist inhibited the actions of the agonist, thereby suggesting that the action of DA was through its D receptors in the endothelial cells. To our knowledge, this study is the first to report DA-mediated regulation of pathogenesis and progression of UVB-induced premalignant skin lesions. PREVENTION RELEVANCE: This investigation demonstrates the role of dopamine and its D receptors in UVB induced premalignant squamous cell skin lesions and how DA through its D receptors inhibits the development and progression of these lesions and subsequently prevents squamous cell carcinoma of the skin.