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and Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against Candida auris. | LitMetric
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and Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against Candida auris.

Janet Herrada Ahmed Gamal Lisa Long Sonia P Sanchez Thomas S McCormick Mahmoud A Ghannoum

Antimicrob Agents Chemother

Center for Medical Mycology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Published: May 2021

Antifungal activity of AmBisome against was determined and AmBisome showed MIC and MIC values of 1 and 2 μg/ml, respectively. Unlike conventional amphotericin B, significant efficacy was observed in the AmBisome 7.5 mg/kg treatment group in survival and reduction of kidney tissue fungal burden compared to the untreated group. Our data show that AmBisome has significant antifungal activity against infection and .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316017PMC
http://dx.doi.org/10.1128/AAC.00306-21DOI Listing

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