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Ten-year update of HOBOE phase III trial comparing triptorelin plus either tamoxifen or letrozole or zoledronic acid + letrozole in premenopausal hormone receptor-positive early breast cancer patients.
ESMO Open
January 2025
Clinical Trial Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy. Electronic address:
Background: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone receptor-positive (HR+) early breast cancer (BC). Here we report the long-term follow-up analysis.
Patients And Methods: HOBOE (ClinicalTrials.
Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study.
Pediatr Rheumatol Online J
January 2025
Division of Pediatric Rheumatology, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.
Background: NSAIDs are commonly used as first line therapy in chronic nonbacterial osteomyelitis (CNO) but are not effective for all patients. The objective of this study was to identify clinical variables associated with NSAID monotherapy response versus requiring second-line medication in a single-center cohort of patients with CNO.
Methods: The charts of children with CNO who attended a CNO clinic at a quaternary care center between 1/1/05 and 7/31/21 were retrospectively reviewed.
Understanding the Scale and Nature of Parent/Guardian Telephone Calls to a Tertiary Children's Cardiac Centre: A Service Evaluation.
Compr Child Adolesc Nurs
January 2025
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Heart defects are the second most common congenital anomaly in babies born in the UK and standards state families should have access to a children's cardiac nurse specialist telephone advice service. However, there is little published information to describe the nature of calls and the workload associated with telephone support. We conducted a prospective service evaluation of telephone calls received at one UK specialist children's cardiac surgical center from parents/carers (April-June 2019).
View Article and Find Full Text PDFThe Effect of Novel Laser-Activated Bleaching Protocols on the Color Change of Non-Vital Anterior Teeth: An In Vitro Study.
Eur J Dent
December 2024
Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Objective: This study compares the color change of non-vital anterior teeth after laser-activated bleaching and conventional walking bleaching technique.
Materials And Methods: Sixty extracted teeth were endodontically treated, stained in a black tea solution, and the baseline shade was measured using a spectrophotometer (Easyshade, VITA). Bleaching was done using either: internal bleaching with 35% HO (Opalescence Endo) and then tooth sealed for 5 days (Gr1), 35% HO (JW Next) for 7 minutes (Gr2), internal and external bleaching for 7 minutes (Gr3), diode laser-activated internal bleaching for 30 seconds (940 nm, continuous wave, 2 W, noncontact mode, 300 um, non-initiated tip), wait for 7 minutes, second laser application for 30 seconds, tooth sealed for 5 days (Gr4), diode laser-activated internal bleaching for 24 hours (Gr5), or diode laser-activated internal and external bleaching for 24 hours (Gr6) ( = 10).
Single-use versus multiple-use endotracheal suction catheters flushed with chlorhexidine in mechanically ventilated ICU patients: A study protocol of a feasibility randomized controlled trial with an embedded qualitative study.
Nurs Crit Care
January 2025
Faculty of Health, School of Nursing and Midwifery, University of Plymouth, Plymouth, UK.
Background: Endotracheal suction catheters are often used multiple times during endotracheal suctioning procedures in resource-limited intensive care units (ICU). The impact of this practice on mechanically ventilated patients' outcomes remains unclear.
Aim: The aim of this feasibility randomized controlled trial (fRCT) is to assess the feasibility and acceptability of single-use versus multiple-use endotracheal suction catheters flushed with chlorhexidine in mechanically ventilated ICU patients.
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