AI Article Synopsis
- MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression after transcription and are involved in key biological processes and disease mechanisms, like cancer and heart disease.
- Advancements in molecular technology have improved our understanding and detection of miRNAs, making them potential diagnostic and therapeutic markers found in various body fluids.
- While most research focuses on blood as a source for circulating miRNAs, this review emphasizes the need for increased study on salivary miRNAs, outlining collection methods and their clinical applications.
Article Abstract
MicroRNAs (miRNAs) are non-coding RNAs ranging from 18-24 nucleotides, also known to regulate the human genome mainly at the post-transcriptional level. MiRNAs were shown to play an important role in most biological processes such as apoptosis and in the pathogenesis of many diseases such as cardiovascular diseases and cancer. Recent developments of advanced molecular high-throughput technologies have enhanced our knowledge of miRNAs. MiRNAs can now be discovered, interrogated, and quantified in various body fluids serving as diagnostic and therapeutic markers for many diseases. While most studies use blood as a sample source to measure circulating miRNAs as possible biomarkers for disease pathogenesis, fewer studies have assessed the role of salivary miRNAs in health and disease. This review aims at providing an overview of the current knowledge of the salivary miRNome, addressing the technical aspects of saliva sampling, and highlighting the applicability of miRNA screening to clinical practice.
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| http://dx.doi.org/10.2174/2211536610666210412154455 | DOI Listing |
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