AI Article Synopsis
Article Abstract
Gynostemma pentaphyllum (Thunb.) Makino has a long history as food and diary supplement in China. At present, there are some products for hyperlipidemia in the market, including G. pentaphyllum tea, healthy wine and healthy food. In order to discover proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, fourteen new triterpenoid saponins named gypenoside LXXXVIII-CI (1-14) along with six known compounds (15-20) were isolated from G. pentaphyllum. Their structures were elucidated by means of various spectroscopic techniques. Eight isolates were evaluated the inhibitory effect on PCSK9 in HepG2 cells. The results showed that three dammarane-type glycosides (2, 3, 15) remarkably reduced PCSK9 expression at 10 μM concentration. These findings suggested that G. pentaphyllum was worthy of further investigation to find small molecule PCSK9 inhibitors and facilitate their utilization as functional food ingredients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bioorg.2021.104843 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis.
Molecules
December 2024
School of Functional Food & Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Article Synopsis
- Ginseng contains rare compounds called ginsenosides, specifically 25-OH-PPT (T19), known for beneficial effects like lowering blood sugar and reducing inflammation.
- The research focused on optimizing the process to extract T19 from ginseng stems and leaves, utilizing different acids and hydrolysis conditions to maximize yield safely.
- Results showed that hydrochloric acid increased T19 content significantly, while citric acid was safer; additionally, T19 demonstrated protective effects on heart cells by reducing oxidative stress and impacting fibrosis markers.
Existing Forms of Notoginsenoside R in Rats and Their Potential Bioactivities.
J Agric Food Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Article Synopsis
- - Notoginsenoside R (NG-R), a key saponin in a medicinal plant, was analyzed using advanced UHPLC-ESI-Q-TOF-MS/MS techniques to identify its various forms and distribution in rats, resulting in the detection of 105 metabolites, including 89 new ones.
- - The study proposed a new fragmentation pathway for protopanaxatriol (PPT) and revealed novel metabolic reactions for NG-R, such as polyhydroxylation and glucuronidation, with significant metabolite accumulation observed in various organs.
- - Predictive analyses suggested 48 metabolites may have therapeutic effects on three diseases, with follow-up experiments confirming anti-tumor and anti-inflammatory properties in eight specific
De Novo Biosynthesis of a Polyene-Type Ginsenoside Precursor Dammaradienol in .
ACS Synth Biol
December 2024
Guangdong Engineering Research Center of Biosynthesis and Metabolism of Effective Components of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Typical dammarane-type ginsenosides are well-known tetracyclic triterpenoids with significant pharmacological effects including antitumor, cardiovascular protection, and neuroprotection. Polyene-type ginsenosides exhibit stronger biological activities than common ginsenosides; however, their contents are low, and most are converted from ginsenosides through a series of processing steps, resulting in higher preparation costs. In this study, a dammaradienol synthase, AarOSC20433, was identified for the first time from H.
View Article and Find Full Text PDFCyclocarysaponins A-J, dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus.
Chin J Nat Med
October 2024
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address:
Ten previously undescribed dammarane-type triterpenoid glycosides, cyclocarysaponins A-J (1-10), were isolated from the leaves of Cyclocarya paliurus (Batal.) Iljinskaja. The structures of these compounds were characterized through detailed spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!