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| http://dx.doi.org/10.1161/CIRCULATIONAHA.120.052531 | DOI Listing |
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Chronic in utero mitral inflow obstruction unloads left ventricular volume in a novel late gestation fetal lamb model.
JTCVS Open
December 2023
Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at Emory University Hospital Midtown, Atlanta, Ga.
Objective: The in utero no flow/no grow hypothesis postulates that reduced inflow of blood into the left ventricle due to a stenotic mitral valve could lead to ventricular hypoplasia and hypoplastic left heart syndrome. This has been demonstrated in chick embryos, but less so in large animals. We investigated the impact of mitral obstruction on left and right ventricular growth in fetal lambs.
View Article and Find Full Text PDFUnloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease: Barriers and Opportunities.
Circulation
April 2021
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN (W.D.M.).
Clinical Outcome of Extraanatomic Bypass for Midaortic Syndrome Caused by Takayasu Arteritis.
Ann Thorac Surg
May 2020
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: We investigated long-term outcomes and cardiac function after extraanatomic bypass surgery for Takayasu arteritis and midaortic syndrome.
Methods: Between 2007 and 2016, 14 patients underwent extraanatomic bypass for Takayasu arteritis. Median age was 56.
Failure rates and complications of interspinous process decompression devices: a European multicenter study.
Neurosurg Focus
October 2015
Department of Neurosurgery and Spinal Surgery, Ruppiner Kliniken, Neuruppin, Germany.
OBJECT Spacers placed between the lumbar spinous processes represent a promising surgical treatment alternative for a variety of spinal pathologies. They provide an unloading distractive force to the stenotic motion segment, restoring foraminal height, and have the potential to relieve symptoms of degenerative disc disease. The authors performed a retrospective, multicenter nonrandomized study consisting of 1108 patients to evaluate implant survival and failure modes after the implantation of 8 different interspinous process devices (IPDs).
View Article and Find Full Text PDFEffects of intra-aortic balloon counterpulsation on coronary pressure in patients with stenotic coronary arteries.
Am Heart J
October 2007
Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Background: The benefits of intra-aortic balloon pumping (IABP) usage reportedly occur through systolic unloading of the left ventricle and the augmentation of diastolic coronary flow. The aim of this study was to assess the change in intracoronary pressure distal to the coronary stenosis after the IABP by using an intracoronary pressure wire.
Methods: Hemodynamic variables and intracoronary pressure data were measured in 16 patients requiring IABP for clinical indication (11 vessels with coronary stenosis and 5 normal vessels were enrolled).
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