AI Article Synopsis
- Genistein (GEN) is a phytoestrogen that interacts with estrogen receptors in the brain, potentially influencing functions like learning and memory.
- A study with male mice was conducted to analyze the effects of GEN on learning and memory, with one group receiving GEN and the other a control treatment.
- The results indicated that GEN-treated mice showed improved learning and memory, as evidenced by their behavior in the novel object recognition test and increased expression of the ERK1/2 protein in their brains.
Article Abstract
Genistein (GEN) is a well known phytoestrogen. It acts through estrogen receptor (ER) and performs plethora of functions in the brain. ERK1/2 is an activated kinase which involves in neuron differentiation, adult neurogenesis and several brain functions including learning and memory. However, GEN dependent expression of ERK1/2 and its effect in learning and memory of mice are unknown. In this study, male mice of 25weeks weighing 30 g were used for the experiments. Mice were placed in two groups- control (C) and genistein treated (GEN). Treated group received GEN dissolved in sesame oil (1 mg/kg/day) whereas the control group received sesame oil only. To study the effects of GEN on learning and memory, open-field (OF) test and novel object recognition (NOR) test were performed. Moreover, immunoblotting (IB) was performed to check the expression of ERK1/2 in the mouse brain of both groups. In the OF test, no significant change was observed in motor activity and anxiety in GEN treated mice as compared to control. Moreover, NOR test suggested that entry towards the dissimilar object was higher in case of GEN treated mice as compared to control. These findings suggest higher learning and memory of GEN treated mice than of control. IB showed that the expression of ERK1/2 was significantly high in GEN treated mouse brain as compared to control. Such study may be helpful to understand GEN mediated learning and memory involving ERK1/2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019993 | PMC |
| http://dx.doi.org/10.1016/j.ibneur.2021.01.005 | DOI Listing |
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