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Introduction: Age-associated depletion in nicotinamide adenine dinucleotide (NAD+) concentrations has been implicated in metabolic, cardiovascular, and neurodegenerative disorders. Supplementation with NAD+ precursors, such as nicotinamide riboside (NR), offers a potential therapeutic avenue against neurodegenerative pathologies in aging, Alzheimer's disease, and related dementias. A crossover, double-blind, randomized placebo (PBO) controlled trial was conducted to test the safety and efficacy of 8 weeks' active treatment with NR (1 g/day) on cognition and plasma AD biomarkers in older adults with subjective cognitive decline and mild cognitive impairment.
View Article and Find Full Text PDFOver the past decade, there has been a global increase in the incidence of skin cancers. Skin cancer has serious consequences if left untreated, potentially leading to more advanced cancer stages. In recent years, deep learning based convolutional neural network have emerged as powerful tools for skin cancer detection.
View Article and Find Full Text PDFThe Study of Adolescent Resilience (SOAR): a research protocol.
Front Child Adolesc Psychiatry
March 2024
Military Population Health Directorate, Naval Health Research Center, San Diego, CA, United States.
Background: Adolescence is a particularly sensitive period of development for military-connected youth, given the socioemotional and physical changes that occur against the backdrop of the military career of their parent(s). Military-connected adolescents face unique stressors relative to their civilian counterparts, such as military relocations, parental absence due to deployments and trainings, and parental military-related physical and mental injury. These stressors may change family dynamics and disrupt social support networks, which can have lasting implications for adolescent health and well-being.
View Article and Find Full Text PDFPhotodegradation, kinetics and non-linear error functions of methylene blue dye using SrZrO perovskite photocatalyst.
Heliyon
July 2024
Nano-optoelectronic Research Laboratory, School of Physics, Universiti Sains Malaysia, 11800, Pinang, Malaysia.
The degradation of methylene blue dye-contaminated wastewater via photocatalysis is an efficient approach towards environmental remediation. The SrZrO perovskite photocatalyst was synthesized using the modified Pechini sol-gel method, and characterized using XRD, FESEM, FTIR, and UV-visible spectrophotometer. Crystallite size obtained by the Scherrer and Williamson-Hall methods were 45.
View Article and Find Full Text PDFLight-induced Enhancement of Energetic Charge Carrier Extraction and Modulation of Local Charge Density to Impact Selectivity in Plasmonic Nanometals.
Angew Chem Int Ed Engl
January 2025
Nankai University, Department of Chemistry, Weijin road, 300071, Tianjin, CHINA.
Localized surface plasmon resonance (LSPR) metals exhibit remarkable light-absorbing property and unique catalytic activity, attracting significant attention in photocatalysts recently. However, the practical application of plasmonic nanometal is hindered by challenge of energetic electrons extraction and low selectivity. The energetic carriers generated in nanometal under illumination have extremely short lifetimes, leading to rapid energy loss.
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