[Troponin T cardiac analysis: clinical cases of the limits of its cardiospecificity].

Ann Biol Clin (Paris)

Laboratoire de biochimie-toxicologie médicale, Hôpital Pontchaillou, CHU Rennes, Rennes, France, Université Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) UMR S 1085, Rennes, France.

Published: April 2021

Introduction: Myositis are systemic diseases, in which heart damage is possible. Cardiac troponin T is often found to be defective to detect cardiac involvement.

Observation: We report cases of two patients with a myositis. Diagnosis was retained based on muscle pain, increase in serum creatinine kinase, and inflammatory muscle damage on MRI. Histology confirmed the diagnosis for one of the two patients. Cardiac troponin T was measured in both patients, to detect myocardial involvement. Despite a serum elevation of this marker, cardiological assessment remained negative (electrocardiogram, cardiac ultrasound, cardiac MRI). Cardiac troponin I was normal in serum because of the absence of correlation with peripheral muscle involvement.

Conclusion: Cardiac troponin T is correlated with muscle involvement in patients with myositis. Cardiac troponin I should be preferred because of a better specificity.

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http://dx.doi.org/10.1684/abc.2021.1637DOI Listing

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