Objective: To study the efficacy and safety of mycophenolate mofetil (MMF) versus cyclophosphamide (CTX) in the treatment of children with Henoch-Schönlein purpura nephritis (HSPN) and nephrotic-range proteinuria.
Methods: A prospective clinical trial was conducted in 68 pediatric patients who were admitted to the Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics and who were diagnosed with HSPN and nephrotic-range proteinuria from August 2016 to November 2019. The patients were randomly divided into two groups:MMF treatment (=33) and CTX treatment (=35). The two groups were compared in terms of complete remission rate, response rate (complete remission + partial remission), urinary protein clearance time, and adverse events.
Results: At months 3, 6, and 12 of treatment, there was no significant difference in the complete remission rate and the response rate between the MMF treament and CTX treatment groups ( > 0.05). There was also no significant difference between the two groups in the urinary protein clearance time and the incidence rate of adverse events ( > 0.05).
Conclusions: MMF and CTX have similar efficacy and safety in the treatment of HSPN children with nephrotic-range proteinuria.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050539 | PMC |
| http://dx.doi.org/10.7499/j.issn.1008-8830.2012145 | DOI Listing |
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