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| http://dx.doi.org/10.1007/s10856-021-06518-6 | DOI Listing |
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Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa.
Adv Mater
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Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 1UL, UK.
Base editing, a CRISPR-based genome editing technology, enables precise correction of single-nucleotide variants, promising resolutive treatment for monogenic genetic disorders like recessive dystrophic epidermolysis bullosa (RDEB). However, the application of base editors in cell manufacturing is hindered by inconsistent efficiency and high costs, contributed by suboptimal delivery methods. Nanoneedles have emerged as an effective delivery approach, enabling highly efficient, non-perturbing gene therapies both in vitro and in vivo.
View Article and Find Full Text PDFSpectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism.
Sovrem Tekhnologii Med
March 2025
Junior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.
Unlabelled: is to study the interaction of methylene blue (MB) with NADH, FADH coenzymes and lactate, and to evaluate a long-term effect of its intravenous or oral introduction on tumor metabolism .
Materials And Methods: The MB interaction with NADH, FADH coenzymes and lactate was studied using absorption spectrophotometry. A long-term effect of MB on tumor metabolism was investigated on a mice model of Ehrlich carcinoma.
Haplotype-based association between paternal DNMT1 variants and nonsyndromic cleft lip or without cleft palate in Chile.
J World Fed Orthod
March 2025
Institute for Research in Dental Sciences, School of Dentistry, Universidad de Chile, Santiago, Chile. Electronic address:
Background: DNA methyltransferase 1 (DNMT1) is responsible for epigenetic remodeling of the genome during spermatogenesis and maintenance of DNA methylation. The current study aimed to assess the possible association between paternal polymorphic variants of the gene encoding DNMT1 enzyme and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression in offspring.
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Magn Reson Med
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Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Purpose: This study aims to develop a free-breathing cardiac DTI method with fast and robust motion correction.
Methods: Two proposed image registration-based motion correction (MOCO) strategies, MOCO and MOCO, were applied to diffusion-weighted images acquired with M2 diffusion gradients under free-breathing. The effectiveness of MOCO was assessed by tracking epicardium pixel positions across image frames.
High-resolution, volumetric diffusion-weighted MR spectroscopic imaging of the brain.
Magn Reson Med
March 2025
Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Purpose: To achieve high-resolution, three-dimensional (3D) quantitative diffusion-weighted MR spectroscopic imaging (DW-MRSI) for molecule-specific microstructural imaging of the brain.
Methods: We introduced and integrated several innovative acquisition and processing strategies for DW-MRSI: (a) a new double-spin-echo sequence combining selective excitation, bipolar diffusion encoding, rapid spatiospectral sampling, interleaved water spectroscopic imaging data, and a special sparsely sampled echo-volume-imaging (EVI)-based navigator, (b) a rank-constrained time-resolved reconstruction from the EVI data to capture spatially varying phases, (c) a model-based phase correction for DW-MRSI data, and (d) a multi-b-value subspace-based method for water/lipids removal and spatiospectral reconstruction using learned metabolite subspaces, and e) a hybrid subspace and parametric model-based parameter estimation strategy. Phantom and in vivo experiments were performed to validate the proposed method and demonstrate its ability to map metabolite-specific diffusion parameters in 3D.
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