AI Article Synopsis
- Incretin hormones like GLP-1 help lower glucose levels, reduce appetite, and protect the heart, but their effects on fat tissue are not fully understood.
- Researchers investigated how liraglutide, a synthetic version of GLP-1, affects fat cell development and insulin sensitivity in 3T3-L1 adipocytes.
- The study found that liraglutide improves insulin sensitivity in mature fat cells through mechanisms involving adenylate cyclase, suggesting that it has a beneficial impact on fatty tissue.
Article Abstract
Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1134/S000629792103010X | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!