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Topical Protection of Esophageal Mucosa as a New Treatment of GERD.
J Clin Gastroenterol
January 2025
Department of Surgery, Oncology and Gastroenterology, University of Padua.
Among the various factors implicated in the pathogenesis of gastroesophageal reflux disease (GERD), visceral hypersensitivity and mucosal resistance have been recently re-evaluated in relation to the increasing phenomenon of proton pump inhibitor failure, particularly in patients with nonerosive reflux disease (NERD). Intensive research has allowed us to understand that noxious substances contained in the refluxate are able to interact with esophageal epithelium and to induce the elicitation of symptoms. The frequent evidence of microscopic esophagitis able to increase the permeability of the mucosa, the proximity of sensory afferent nerve fibers to the esophageal lumen favoring the higher sensitivity to noxious substances and the possible activation of inflammatory pathways interacting with sensory nerve endings are pathophysiological alterations confirming that mucosal resistance is impaired in GERD patients.
View Article and Find Full Text PDF[Consensus for the treatment of atopic dermatitis in primary care: resolving myths and legends based on evidence].
Rev Alerg Mex
December 2024
Universidad Espíritu Santo, Samborondón, Guayas, Ecuador.
Article Synopsis
- Atopic dermatitis (AD) greatly affects patients' quality of life, and existing guidelines often target specialists instead of primary care physicians (PCPs).
- A study aimed to create a consensus document specifically for PCPs, offering evidence-based recommendations to enhance AD patient diagnosis and management.
- The document identifies obstacles PCPs face in implementing guidelines and provides consensus solutions to improve care for AD patients across different medical specialties.
Complications of Nonsurgical Rhinoplasty with Hyaluronic Acid Injections: A Narrative Review.
Aesthetic Plast Surg
January 2025
Primus Medical Center (GVM), Gruppo Otorinolaringoiatrico della Romagna, Via Punta di Ferro 2/c, 47122, Forlì, FC, Italy.
Background: The increasing popularity of cosmetic procedures has led to a rise in both surgical and nonsurgical interventions. Rhinoplasty, particularly nonsurgical rhinoplasty using injectable fillers such as hyaluronic acid (HA), has become highly sought after due to its minimally invasive nature. Despite its benefits, complications can occur, ranging from minor to severe.
View Article and Find Full Text PDFHuman birth tissue products as a non-opioid medicine to inhibit post-surgical pain.
Elife
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, United States.
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain.
View Article and Find Full Text PDFPolysaccharide-based hydrogels for atopic dermatitis management: A review.
Carbohydr Polym
February 2025
School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia. Electronic address:
Atopic dermatitis (AD) is the most common form of eczema and the most burdensome skin disease globally, affecting nearly 223 million. A major AD predisposition is genetic susceptibility, affecting skin barrier integrity and cell-mediated immunity. Manifesting as red, dry, and itchy skin, basic treatment involves skin hydration with emollients.
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