Purpose: To investigate the dependence of dissolved Xe chemical shift on the fraction of inhaled oxygen, F O , in the lungs of healthy rats.
Methods: The chemical shifts of Xe dissolved in red blood cells, δ , and blood plasma and/or tissue, δ , were measured using MRS in 12 Sprague Dawley rats mechanically ventilated at F O values of 0.14, 0.19, and 0.22. Regional effects on the chemical shifts were controlled using a chemical shift saturation recovery sequence with a fixed delay time. MRS was also performed at an F CO value of 0.085 to investigate the potential effect of the vascular response on δ and δ .
Results: δ increased with decreasing F O (P = .0002), and δ showed no dependence on F O (P = .23). δ at F CO = 0 (210.7 ppm ± 0.1) and at F CO = 0.085 (210.6 ppm ± 0.2) were not significantly different (P = .67). δ at F CO = 0 (196.9 ppm ± 0.3) and at F CO = 0.085 (197.0 ppm ± 0.1) were also not significantly different (P = .81).
Conclusion: Rat lung δ showed an inverse relationship to F O , opposite to the relationship previously demonstrated for in vitro human blood. Rat lung δ did not depend on F CO .
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