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Unveiling Microscopic Variations during Photodynamic Therapy via Polarity-Responsive Fluorescence Lifetime Imaging.
Anal Chem
January 2025
Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China.
Photodynamic therapy is a highly promising method for cancer adjuvant treatment. However, the current research on the microscopic changes during the photodynamic therapy process is still quite limited, which seriously impedes the deep understanding of the procedure. For this purpose, a novel polarity-responsive probe, , with excellent mitochondrial targeting and anchoring capabilities has been rationally designed and synthesized.
View Article and Find Full Text PDFEnhanced Accumulation and Penetration of Magnetic Nanoclusters in Tumors Using an 8-Magnet Halbach Array Leads to Improved Cancer Treatment.
ACS Nano
January 2025
Department of Bioengineering, University of Pennsylvania, 210 S. 33rd Street, 435 Skirkanich Hall, Philadelphia, Pennsylvania 19104, United States.
Nanoparticles have gained attention as drug delivery vehicles for cancer treatment, but often struggle with poor tumor accumulation and penetration. Single external magnets can enhance magnetic nanoparticle delivery but are limited to superficial tumors due to the rapid decline in the magnetic field strength with distance. We previously showed that a 2-magnet device could extend targeting to greater tissue depths.
View Article and Find Full Text PDFSafety of repeated low-level red-light therapy for myopia: A systematic review.
Asia Pac J Ophthalmol (Phila)
December 2024
Center for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong, China. Electronic address:
Purpose: Establishing the safety profile of repeated low-level red-light (RLRL) therapy is necessary prior to its widespread clinical implementation.
Methods: We conducted a systematic review (International Prospective Register of Systematic Reviews, CRD42024516676) of articles across seven databases from inception through February 10, 2024, with keywords related to myopia and RLRL therapy. Pooled safety outcomes and risk-to-benefit ratios were reported, and incidence of side effects was compared with other antimyopia interventions.
Role of Sleep in Depressive Disorders and the Potential Therapeutic Role of Short-Term Sleep Deprivation and Light Therapy: A Review.
Med Sci Monit
November 2024
II Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, Lublin, Poland.
Depression affects about 280 million people globally and is marked by persistent sadness and impaired daily functioning. Sleep disturbances are prevalent in major depressive disorder, affecting roughly 90% of patients, and are linked to the severity and progression of depression. This review emphasizes the critical role of sleep in depressive disorders and evaluates the alternative treatments bright light therapy and sleep deprivation.
View Article and Find Full Text PDFSupportive Care for Common Conditions in Small Vulnerable Newborns and Term Infants: The Evidence.
Neonatology
November 2024
Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Introduction: Small vulnerable newborns (SVNs) are at an increased risk of early death and other morbidities. Essential interventions provided to SVN, and other high-risk newborns have been proven critical in improving their outcomes. We aimed to provide an update on the effectiveness and safety of these interventions in low- and middle-income countries (LMICs).
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