Background: Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions.
Results: A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5-1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05.
Conclusions: Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034140 | PMC |
| http://dx.doi.org/10.1186/s12863-021-00968-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic strategies to facilitate breeding for increased β-Glucan content in oat (Avena sativa L.).
BMC Genomics
January 2025
Department of Agronomy, Horticulture, and Plant Science, South Dakota State University (SDSU), Brookings, SD, 57007, USA.
Background: Hexaploid oat (Avena sativa L.) is a commercially important cereal crop due to its soluble dietary fiber β-glucan, a hemicellulose known to prevent cardio-vascular diseases. To maximize health benefits associated with the consumption of oat-based food products, breeding efforts have aimed at increasing the β-glucan content in oat groats.
View Article and Find Full Text PDFUnveiling alfalfa root rot resistance genes through an integrative GWAS and transcriptome study.
BMC Plant Biol
January 2025
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Background: Root rot is a major disease affecting alfalfa (Medicago sativa L.), causing significant yield losses and economic damage. The primary pathogens include Fusarium spp.
View Article and Find Full Text PDFGenome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat.
BMC Genomics
January 2025
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Background: Identifying markers or genes crucial for growth traits in Zhongwei goats is pivotal for breeding. Pinpointing genetic factors linked to body size gain enhances breeding efficiency and economic value. In this study, we used the MGISEQ-T7 platform to re-sequence 240 Zhongwei goats (133 male; 107 female) belonging to 5 metrics of growth traits at different growth stages (40 days and 6 months, here in after referred to as 40d and 6 m), namely, Body Weight (BW), Body Height (BH), Body Length (BL), Chest Circumference (CC), Tube Circumference (TC) were examined.
View Article and Find Full Text PDFThe impact of metabolic syndrome on hepatocellular carcinoma: a mendelian randomization study.
Sci Rep
January 2025
Medical Innovation Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwai Main Street, Nanchang, 330006, Jiangxi, China.
Traditional epidemiological studies are susceptible to confounding factors. To clarify the impact of metabolic syndrome and its diagnostic components on hepatocellular carcinoma, we conducted a preliminary mendelian randomization analysis with metabolic syndrome and its diagnostic components as exposures and hepatocellular carcinoma as the outcome. Another set of genetic data related to hepatocellular carcinoma was used as a validation cohort, repeating the mendelian randomization analysis and combining the two groups for a meta-analysis.
View Article and Find Full Text PDFParallel genetic adaptation amid a background of changing effective population sizes in divergent yellow perch () populations.
Proc Biol Sci
January 2025
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-2054, USA.
Aquatic ecosystems are highly dynamic environments vulnerable to natural and anthropogenic disturbances. High-economic-value fisheries are one of many ecosystem services affected by these disturbances, and it is critical to accurately characterize the genetic diversity and effective population sizes of valuable fish stocks through time. We used genome-wide data to reconstruct the demographic histories of economically important yellow perch () populations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!