AI Article Synopsis

  • Oral Squamous Cell Carcinoma (OSCC) is a serious cancer with high mortality, and understanding immune system interactions is vital for personalized treatment.
  • The study analyzed 73 OSCC patients and 149 healthy controls in Bulgaria, focusing on genetic variations (polymorphisms) of MICA and MICB genes using advanced DNA sequencing and measuring protein levels in the blood.
  • Results indicated that certain MICB alleles were associated with reduced OSCC risk, while others increased risk, highlighting the potential role of MICB in immune response and cancer development, with implications for better targeting treatments.

Article Abstract

Background: Oral Squamous Cell Carcinoma (OSCC) is a malignancy characterized by an aggressive tumor growth and significant mortality. Clarifying mechanisms responsible for immunomodulation are among the main challenges for the development of personalized approaches for the management of patients with Oral Squamous Cell Carcinoma. The aim of the present study was to analyze the relevance of MICA and MICB to Oral Squamous Cell Carcinoma pathogenesis focusing on allele polymorphisms and the levels of soluble MICA and MICB molecules.

Materials And Methods: 73 patients diagnosed with Oral Squamous Cell Carcinoma and 149 healthy controls from the Bulgarian population were included in the study. MICA and MICB polymorphism was analyzed at high-resolution level using Next-Generation Sequencing. Serum levels of soluble MICA and MICB molecules were measured by ELISA.

Results: Our results show significant protective association with MICB*002:01, while relatively rare alleles MICB*018, *019, and *020 were observed with statistically significant increased frequency in Oral Squamous Cell Carcinoma patients compared to controls. Additionally, a predisposing association was observed for MICA*008:01-MICB*019 haplotype. A correlation analysis between functionally relevant MICA polymorphisms and sMICA showed that homozygosity for MICA-A5.1 or 129Val in OSCC patients was associated with significantly higher serum levels of sMICA.

Conclusion: This is the first study showing significant associations between MICB alleles and Oral Squamous Cell Carcinoma and suggesting the possible role of MICB in immunosurveillance in Oral Squamous Cell Carcinoma development. Observed correlations between the levels of soluble MICA molecules and functionally relevant polymorphisms might represent a further step toward a better understanding of molecular mechanisms of Oral Squamous Cell Carcinoma and developing strategies for therapeutic targeting harnessing effective immunosurveillance.

Download full-text PDF

Source
http://dx.doi.org/10.1111/jop.13185DOI Listing

Publication Analysis

Top Keywords

oral squamous
36
squamous cell
36
cell carcinoma
36
mica micb
24
levels soluble
16
soluble mica
16
oral
9
squamous
9
cell
9
carcinoma
9

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!