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Aluminum Induces Neurotoxicity through the MicroRNA-98-5p/Insulin-like Growth Factor 2 Axis.
ACS Chem Neurosci
January 2025
Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Aluminum is a well-known and widely distributed environmental neurotoxin. This study aimed to investigate the effect of miR-98-5p targeting insulin-like growth factor 2 (IGF2) on aluminum neurotoxicity. Thirty-two Sprague-Dawley rats were randomly divided into four groups and administered 0, 10, 20, and 40 μmol/kg maltol aluminum [Al(mal)], respectively.
View Article and Find Full Text PDFAddressing Water Scarcity to Achieve Climate Resilience and Human Health.
Integr Environ Assess Manag
January 2025
Department of Medicine, Division of Occupational, Environmental and Climate Medicine, University of California, San Francisco; San Francisco, California, 94158United States.
Water scarcity is projected to affect half of the world's population, gradually exacerbated by climate change. This article elaborates from a panel discussion at the 2023 United Nations Water Conference on Addressing Water Scarcity to Achieve Climate Resilience and Human Health. Understanding and addressing water scarcity goes beyond hydrological water balances to also include societal and economic measures.
View Article and Find Full Text PDFLong-term climate establishes functional legacies by altering microbial traits.
ISME J
January 2025
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC 27607, United States.
Long-term climate history can influence rates of soil carbon cycling but the microbial traits underlying these legacy effects are not well understood. Legacies may result if historical climate differences alter the traits of soil microbial communities, particularly those associated with carbon cycling and stress tolerance. However, it is also possible that contemporary conditions can overcome the influence of historical climate, particularly under extreme conditions.
View Article and Find Full Text PDFFive-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension.
JAMA Neurol
January 2025
Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.
Importance: There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) and on RNA interference (RNAi) therapeutics in general. This study presents the longest-term data to date on patisiran for hATTR-PN.
Objective: To present the long-term efficacy and safety of patisiran in adults with hATTR-PN.
Fluid Distribution: Response to Intermittent Pneumatic Compression in People With and Without Primary Lymphedema.
Lymphat Res Biol
January 2025
Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, Australia.
Current understanding of changes in fluid distribution in response to the application of compression in primary lymphedema (PLE) is limited. This study measured fluid distribution before and after one application of standardized intermittent pneumatic compression (IPC) in the lower limbs of people with PLE, compared with those without lymphedema. High-frequency ultrasound (HFU) was used to measure dermal fluid, bioimpedance to measure segmental fluid, and percent water content (PWC) to measure fluid at specific anatomical points.
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