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A two-sample mendelian randomization study of non-tuberculous mycobacteria infection and lung cancer.
J Thorac Dis
December 2024
Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Background: Non-tuberculous mycobacterial lung disease may coexist or precede lung cancer, yet a causal link remains unproven. This study aimed to elucidate the causal association between non-tuberculous mycobacteria (NTM) and lung cancer.
Methods: Summary data from genome-wide association studies (GWAS) for NTM, atypical mycobacterial lung infections, and various types of lung cancer were utilized.
Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses.
Sci Rep
January 2025
Department of Anesthesiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. This study utilized genome-wide association study (GWAS) summary statistics encompassing 179 lipidomes and six prevalent FRDs, namely polycystic ovary syndrome (PCOS), endometriosis, uterine fibroid, female infertility, uterine endometrial cancer, and ovarian cancer. The two-sample MR (TSMR) approach was employed to investigate the causal relationships, with further validation using false discovery rate (FDR) and multivariable MR (MVMR) methods.
View Article and Find Full Text PDFRelapsing ANCA-associated vasculitis presenting as a mediastinal mass.
BMJ Case Rep
January 2025
Department of Nephrology, Barts Health NHS Trust, London, UK.
Anti-neutrophil cytoplasmic antibody-associated vasculitides (AAV) represent a heterogeneous multisystem group of disorders typified by necrotising inflammation of smaller blood vessels, classically yielding a pauci-immune, crescentic glomerulonephritis. Without prompt treatment, there is a significant risk of irreversible damage and ensuing renal impairment.Diagnosis is often challenging, exacerbated by the disorder's often vague and insidious presentation.
View Article and Find Full Text PDFInteractions of anthropogenic microfibres with the marine macroalga, Ulvalactuca.
Mar Pollut Bull
January 2025
School of Geography, Earth and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK. Electronic address:
Little information exists on the interactions between microfibres (MFs) and marine macroalgae. In this study, the translucent green seaweed, Ulva lactuca, has been exposed to ∼2 mg L suspensions of MFs prepared from dryer lint under controlled conditions, with MFs on the alga surface and remaining in seawater subsequently counted and characterised. MFs were mainly <2 mm and cellulosic, and contained various additives and chemicals used in textile treatment.
View Article and Find Full Text PDFSelf-reported outcomes in adults with hypospadias: A meta-analysis of patient satisfaction and quality-of-life metrics.
J Pediatr Urol
January 2025
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia. Electronic address:
Introduction: Hypospadias reconstruction seeks to correct structural problems associated with this congenital condition to improve patient quality-of-life (QoL) and overall well-being. While corrective surgery can lead to major functional and psychosocial improvements, some patients experience continuing problems that require additional procedures. This study evaluates patient-reported outcomes (PROs) in hypospadias care, particularly penile satisfaction and QoL after surgery, to fill this essential gap in the literature.
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