Introduction: Radiofrequency ablation (RFA) is a demonstrated safe and effective treatment for chronic low back pain. RFA delivers high density electrical current near lumbar medial branch nerve. The success of RFA is contingent upon creating a lesion that overlaps the sensory nerve supplying the affected facet joint(s). Both bipolar-RFA and V-shaped active tip cannulas increase lesion size in experimental models. We describe successful application of concomitant bipolar and V-shaped lesions in a single patient with chronic low back pain caused by lumbar spondylosis.
Case Presentation: An 81-year-old male with atrial fibrillation on chronic warfarin anticoagulation was previously treated with conventional monopolar lumbar facet RFA resulting in a 75% decrement in pain intensity exceeding eight months. Nine months after the procedure, his pain returned with similar pretreatment character and was unresponsive to additional physical therapy and acetaminophen. We elected to use a V-shaped cannula to maximize lesion diameter and lengthen intervals between anticoagulant abstinence to minimize the risk. Intraoperatively, a grounding-pad malfunction compelled us to convert to bipolar-RFA by placing a second adjacent V-shaped cannula, eliminating grounding-pad requirement. Bilateral bipolar medial branch RFA of L3-L4, L4-L5, L5-S1 nerves was performed between these two cannulas without further incident. The patient had sustained analgesia that lasted over twelve months resultant from treatment.
Conclusions: We herein describe a technique of combined bipolar-RFA utilizing proximally adjacent V-shaped cannulas. Both bipolar and V-shaped cannulas create larger lesions in experiments. While both techniques purport theoretical advantages, the clinical superiority of a combined technique warrants continued clinical investigation.
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Sci Rep
October 2024
School of Economics, Ocean University of China, Qingdao, 266100, Shandong, China.
The coordinated development of urban e-commerce and green total factor productivity (GTFP) plays a crucial role in achieving high-quality development. This paper selects relevant data from the eight major urban agglomerations in China for research. A model that described the coupling coordination between the regions' GTFP and urban e-commerce was presented.
View Article and Find Full Text PDFAesthet Surg J Open Forum
April 2023
Background: East Asian beauty standards uphold a V-shaped face and a long slender neck. Some patients are dissatisfied with the concurrent nonsurgical treatment and prefer limited downtime with minimally invasive procedures to achieve a natural skin-tightening outcome. The authors performed bipolar radiofrequency-assisted liposuction (RFAL) to achieve cervical rejuvenation.
View Article and Find Full Text PDFNat Commun
September 2022
Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Accurate segregation of chromosomes during mitosis depends on the correct assembly of the mitotic spindle, a bipolar structure composed mainly of microtubules. The augmin complex, or homologous to augmin subunits (HAUS) complex, is an eight-subunit protein complex required for building robust mitotic spindles in metazoa. Augmin increases microtubule density within the spindle by recruiting the γ-tubulin ring complex (γ-TuRC) to pre-existing microtubules and nucleating branching microtubules.
View Article and Find Full Text PDFBiochem Biophys Rep
July 2022
Medicines Discovery Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Calbindin-D28k is a calcium binding protein that is highly expressed in the mammalian central nervous system. It has been reported that calbindin-D28k binds to and increases the activity of inositol Monophosphatase (IMPase). This is an enzyme that is involved in the homeostasis of the Inositol trisphosphate signalling cascade by catalysing the final dephosphorylation of inositol and has been implicated in the therapeutic mechanism of lithium treatment of bipolar disorder.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2021
Department of Chemistry, Research Institute for Natural Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Three V-shaped host molecules with a cyclohexane linker were successfully synthesized for thermally activated delayed fluorescence organic light-emitting diodes (TADF-OLEDs). The unipolar host molecules, BBCzC and BTDC, contained two 9-phenyl-9-3,9'-bicarbazole (PBCz) moieties and two 2,12-di--butyl-7-phenyl-5,9-dioxa-13-boranaphtho[3,2,1-]anthracene (PDBNA) moieties, respectively. BCzTC, a bipolar host molecule, consisted of a donor unit, PBCz, and an acceptor unit, PDBNA, connected by a cyclohexane linker.
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