A one-flask, two-step procedure from 3-amino-2-methyl-5,6,7,7a-tetrahydro-1-pyrrolizin-1-one affords the secondary metabolites legonmycins A and B - three operations overall from methyl -Boc-prolinate. The key step proceeds in each case via ,-diacylation, then selective oxidative hydrolysis of the intermediate bicyclic pyrrole and establishes a precedent for the synthesis of related C(7a)-hydroxylated pyrrolizidines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871033 | PMC |
| http://dx.doi.org/10.3762/bjoc.17.31 | DOI Listing |
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