AI Article Synopsis
- The study aimed to evaluate the anti-inflammatory effects of different seed extracts at various doses using a method called Soxhlet extraction with n-hexane, chloroform, and methanol.
- Wistar rats were tested with varying doses of the extracts to measure their anti-inflammatory activity, with a standard drug (diclofenac sodium) used as a comparison.
- Results showed that the n-hexane extract had the strongest anti-inflammatory effect, while all tested extracts worked by enhancing GABA neurotransmission and suppressing glutamate receptors.
Article Abstract
Aims And Objectives: The present study was aimed to evaluate the antiinflammatory effect of different seed extracts of at different doses.
Materials And Methods: Three different seed extracts were prepared through Soxhlet extraction method by using n-hexane, chloroform and methanol solvents. Acute toxicity test performed at dose of 400 mg/ kg, 800 mg/kg, 1600 mg/kg and 3200 mg/kg. Two different strengths of seed extracts (minimum therapeutic dose of 500 mg/kg and maximum therapeutic dose of 1000 mg/kg) were given to Wistar rats to measure anti-inflammatory activity through Carrageenan induced paw edema method.
Results: The standard drug diclofenac sodium was (percentage of inhibition of paw edema 29.68%) more effective as compared to test drug. When efficacy of all extracts compared with each other, -hexane extract showed more anti-inflammatory effect (percentage inhibition of paw edema 22.21%) at maximum effective dose 1000 mg/kg.
Conclusion: Seed extracts of showed anti-inflammatory activity by potentiating the neurotransmission of GABA and also by repression glutamate receptor.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021059 | PMC |
| http://dx.doi.org/10.4103/jpbs.JPBS_243_19 | DOI Listing |
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