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Prevalence of Genes in Gram-Negative Bloodstream Isolates across 66 Hospitals in the United States. | LitMetric

AI Article Synopsis

  • * The analysis of 4,209 blood cultures revealed that 11% carried the targeted genes, with specific prevalence rates for various bacterial species, such as 16% for one specific strain and 14% for another.
  • * Only 2% of the tested organisms had carbapenemase genes, highlighting the need for extended molecular diagnostic panels to improve the identification of resistance factors in these bacteria.

Article Abstract

Understanding bacterial species at greatest risk for harboring genes is necessary to guide antibiotic treatment. We identified the species-specific prevalence of genes in Gram-negative clinical isolates from the United States. Twenty-four microbiology laboratories representing 66 hospitals using the GenMark Dx ePlex blood culture identification Gram-negative (BCID-GN) panel extracted blood culture results from April 2019 to July 2020. The BCID-GN panel includes 21 Gram-negative targets. Along with identifying genes, it detects major carbapenemase gene families. A total of 4,209 Gram-negative blood cultures were included. genes were identified in 462 (11%) specimens. The species-specific prevalence of genes was as follows: (16%), (14%), (6%), spp. (6%), (5%), species (3%), (2%), (0.6%), and (0.5%). prevalence was 26%, 24%, and 22% among participating hospitals in the District of Columbia, New York, and Florida, respectively. Carbapenemase genes were identified in 61 (2%) organisms with the following distribution: (59%), (16%), (10%), (8%), and (7%). The species-specific prevalence of carbapenemase genes was as follows: (5%), (3%), (3%), species (3%), spp. (3%), (2%), (<1%), (<1%), and (<1%). Approximately 11% of Gram-negative organisms in our US cohort contain genes. genes remain uncommon in organisms beyond , , and Future molecular diagnostic panels would benefit from the inclusion of plasmid-mediated and SHV and TEM extended-spectrum beta-lactamase (ESBL) targets.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316135PMC
http://dx.doi.org/10.1128/JCM.00127-21DOI Listing

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