AI Article Synopsis
- The study evaluated the efficacy and safety of biosimilar adalimumab in treating Behçet's uveitis patients in Iran, focusing on those who failed conventional treatments.
- A total of 48 patients were followed for an average of 19.24 months, with significant improvements noted in visual acuity, vitreous haze grade, and anterior chamber cell grade after using adalimumab.
- The results indicate that biosimilar adalimumab (CinnoRA®) is both effective and well-tolerated, also reducing the need for corticosteroids.
Article Abstract
Purpose: This study aimed to evaluate biosimilar adalimumab's efficacy and safety in patients with Behçet's uveitis in Iran.
Methods: We performed a study on patients who mostly (79.2%) had a failure on conventional treatment with the mean follow-up time of 19.24 months (95% confidence interval (CI), 16.52-21.96). All the enrolled patients were anti-tumor necrosis factor (anti-TNF) naiive. The primary endpoint was best-corrected visual acuity (BCVA) improvement, and the secondary endpoints were changes in macular thickness, vitreous haze grade, anterior chamber (AC) cell grade, prednisolone dose, and the incidence of adverse reactions.
Results: Forty-eight patients were enrolled in the study. After adalimumab use, visual acuity improved significantly (-value˂.001); vitreous haze grade decreased (-value˂.001), and AC cell grade improved (-value = .002). Macular thickness decreased, but its change was not statistically significant (-value = .1). Moreover, adalimumab showed a corticosteroid-sparing effect (-value = .03).
Conclusion: Biosimilar adalimumab (CinnoRA®) is effective and well-tolerated in Behçet's uveitis.
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| http://dx.doi.org/10.1080/09273948.2021.1900276 | DOI Listing |
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